CAS 14357-78-9|Diprenorphine

Introduction：Basic information about CAS 14357-78-9|Diprenorphine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Diprenorphine BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Diprenorphine
CAS Number	14357-78-9	Molecular Weight	425.56000
Density	1.33 g/cm3	Boiling Point	/
Molecular Formula	C₂₆H₃₅NO₄	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	Diprenorphine,17-(Cyclopropylmethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-α,α-dimethyl-6,14-ethenomorphinan-7-methanol
Synonym	More Synonyms

Diprenorphine BiologicalActivity

Description	Diprenorphine is a non-selective opioid antagonist with Ki values of 0.017, 0.072 and 0.23 nM against κ-, μ- and δ-opioid receptors, respectively[1]. Diprenorphine can be used for central poststroke pain (CPSP) research[1].
Related Catalog	Signaling Pathways >>GPCR/G Protein >>Opioid ReceptorSignaling Pathways >>Neuronal Signaling >>Opioid ReceptorResearch Areas >>Neurological Disease
Target	Ki: 0.017 nM (κ-opioid receptor), 0.072 nM (μ-opioid receptor), 0.23 nM (δ-opioid receptor)[1]
References	[1]. Raynor K, et al. Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors. Mol Pharmacol. 1994 Feb;45(2):330-4. [2]. Willoch F, et al. Central poststroke pain and reduced opioid receptor binding within pain processing circuitries: a [11C]diprenorphine PET study. Pain. 2004 Apr;108(3):213-220.

Chemical & Physical Properties

Density	1.33 g/cm3
Molecular Formula	C₂₆H₃₅NO₄
Molecular Weight	425.56000
Exact Mass	425.25700
PSA	62.16000
LogP	3.32550
Index of Refraction	1.656
InChIKey	OIJXLIIMXHRJJH-KNLIIKEYSA-N
SMILES	COC12CCC3(CC1C(C)(C)O)C1Cc4ccc(O)c5c4C3(CCN1CC1CC1)C2O5

Safety Information

Hazard Codes	Xn: Harmful;
Risk Phrases	R20/21/22

Synonyms

DIPRENORPHINE

RX-5050M

Diprenorphin

DIPRENORPHINE POTENT OPIOID ANTAGON

diprenorpine

M-5050

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