Introduction：Basic information about CAS 143896-17-7|Galanin (1-13)-Pro-Pro-(Ala-Leu-)₂Ala amide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Galanin (1-13)-Pro-Pro-(Ala-Leu-)₂Ala amide |
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| CAS Number | 143896-17-7 | Molecular Weight | 1980.31 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C95H146N22O24 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | m40 |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | M40 is a potent, non-selective galanin receptor antagonist. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Neuropeptide Y ReceptorPeptidesResearch Areas >>Others |
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| In Vitro | M40 (1 μM) displaces [mono[125IJodo-Tyr26]galanin from binding sites in the hippocampus, hypothalamus, and spinal cord. M40 has a lower affinity than galanin for all membranes. The IC50 values are 6 nM in the hippocampus, 15 nM in the hypothalamus, 12 nM in the spinal cord, and 3 nM in the insulinoma cells. M40 (1 μM) completely blocks 125I-labeled galanin-binding sites[1]. |
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| References | [1]. Bartfai T, et al. Galanin-receptor ligand M40 peptide distinguishes between putative galanin-receptor subtypes. Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11287-91. |
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Chemical & Physical Properties
| Molecular Formula | C95H146N22O24 |
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| Molecular Weight | 1980.31 |
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| PSA | 715.21000 |
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| LogP | 2.82290 |
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| InChIKey | OSGCBUDLRBUEGW-JZCUZNMGSA-N |
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| SMILES | CC(C)CC(NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C1CCCN1C(=O)C1CCCN1C(=O)C1CCCN1C(=O)CNC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(Cc1ccc(O)cc1)NC(=O)CNC(=O)C(C)NC(=O)C(CO)NC(=O)C(CC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)CN)C(C)O)C(=O)NC(C)C(N)=O |
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| Storage condition | -20°C |
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Synonyms
| GLY-TRP-THR-LEU-ASN-SER-ALA-GLY-TYR-LEU-LEU-GLY-PRO-PRO-PRO-ALA-LEU-ALA-LEU-ALA-NH2 |
| galanin fragment 1-13-pro-pro-ala-*leu-ala-leu-al |
| GALANIN FRAGMENT 1-13-PRO-PRO-ALA-LEU-ALA-LEU-ALA-AMIDE |
| 8-Bromo-cAMP,sodium salt |
| H-GLY-TRP-THR-LEU-ASN-SER-ALA-GLY-TYR-LEU-LEU-GLY-PRO-PRO-PRO-ALA-LEU-ALA-LEU-ALA-NH2 |
| GWTLNSAGYLLGPPPALALA-NH2 |
