Introduction：Basic information about CAS 151804-77-2|AC187, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | AC187 |
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| CAS Number | 151804-77-2 | Molecular Weight | 2890.21000 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C127H205N37O40 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | ac 187 |
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| Synonym | More Synonyms |
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AC187 BiologicalActivity
| Description | AC 187 is an orally active, potent amylin receptor antagonist (IC50= 0.48 nM) that displays 38-fold and 400-fold selectivity over calcitonin and CGRP receptors respectively. AC 187 blocks amyloid β-induced neurotoxicity by attenuating the activation of initiator and effector caspases in vitro. AC 187 increases glucagon secretion, accelerates gastric emptying, alters plasma glucose levels and increases food intake in vivo. |
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| Related Catalog | Signaling Pathways >>Others >>Others |
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Chemical & Physical Properties
| Molecular Formula | C127H205N37O40 |
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| Molecular Weight | 2890.21000 |
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| Exact Mass | 2888.51000 |
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| PSA | 1275.92000 |
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| InChIKey | ZLFXHYNEZYAYPG-AABHONRUSA-N |
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| SMILES | CC(=O)NC(C(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCC(N)=O)C(=O)NC(CCC(=O)O)C(=O)NC(CC(C)C)C(=O)NC(Cc1c[nH]cn1)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCC(N)=O)C(=O)NC(C(=O)NC(Cc1ccc(O)cc1)C(=O)N1CCCC1C(=O)NC(CCCNC(=N)N)C(=O)NC(C(=O)NC(CC(N)=O)C(=O)NC(C(=O)NCC(=O)NC(CO)C(=O)NC(CC(N)=O)C(=O)NC(C(=O)NC(Cc1ccc(O)cc1)C(N)=O)C(C)O)C(C)O)C(C)O)C(C)O)C(C)C |
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Synonyms
| acetyl-val-leu-gly-lys-leu-ser-gln-glu-leu-his-lys-leu-gln-thr-tyr-pro-arg-thr-asn-thr-gly-ser-asn-thr-tyr-nh2 |
