Introduction：Basic information about CAS 23155-02-4|Fosfomycin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Fosfomycin |
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| CAS Number | 23155-02-4 | Molecular Weight | 138.05900 |
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| Density | 1.561g/cm3 | Boiling Point | 342.651ºC at 760 mmHg |
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| Molecular Formula | C3H7O4P | Melting Point | 94ºC |
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| MSDS | / | Flash Point | 161.03ºC |
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Names
| Name | fosfomycin |
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| Synonym | More Synonyms |
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Fosfomycin BiologicalActivity
| Description | Fosfomycin (MK-0955) is a broad-spectrum antibiotic. Fosfomycin can cross blood-brain barrier penetrating, and irreversibly inhibits an early stage in cell wall synthesis. Fosfomycin shows anti-bacteria activity for a range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria[1][2]. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial |
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| In Vivo | Fosfomycin (80 mg/kg; i.v. or p.o.) displays the protective effect on the nephrotoxicity of double beckacin, and is not affected by different administration routes in rats[3]. Pharmacokinetic of Fosfomycin in Rats[4] Dibekacin Dose (mg) Vdss (l/kg) β (min-1) T1/2 (min) Urinary recovery (%) 30 0.261 0.0244 28.4 85 Animal Model: Fischer 344 rats[3] Dosage: 320 mg/kg Administration: Intramuscular injection, 5 schedules: 1 h, 0.5 h earlier than dibekacin, concomitantly, 0.5 h later and 1 h later; 11 days Result: Reduced polyuria, proteinuria, enzymes and cytosine caused by dibecacin (40 mg/kg), followed by the previous treatment. Animal Model: Dehydrated Wistar rat with acute renal failure (8-week-old)[4] Dosage: 120 mg/kg Administration: Intravenous injection; once Result: Recovered the exclusion rate of rats basically to normal, and improved the nephrotoxicity parameters. Protects proximal tubular lysosomes from aminoglycosides by inhibiting myeloid formation and protecting the integrity of lysosomal membrane of rats treated with double bekacin. |
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| References | [1]. Falagas ME, et al. Fosfomycin. Clin Microbiol Rev. 2016 Apr. 29(2):321-47. [2]. Dijkmans AC, et al. Fosfomycin: Pharmacological, Clinical and Future Perspectives. Antibiotics (Basel). 2017 Oct 31. 6(4):24. [3]. Inouye S, et al. Mode of protective action of fosfomycin against dibekacin-induced nephrotoxicity in the dehydrated rats. J Pharmacobiodyn. 1982 Dec. 5(12):941-50. |
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Chemical & Physical Properties
| Density | 1.561g/cm3 |
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| Boiling Point | 342.651ºC at 760 mmHg |
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| Melting Point | 94ºC |
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| Molecular Formula | C3H7O4P |
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| Molecular Weight | 138.05900 |
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| Flash Point | 161.03ºC |
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| Exact Mass | 138.00800 |
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| PSA | 79.87000 |
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| Vapour Pressure | 0mmHg at 25°C |
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| Index of Refraction | 1.486 |
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| InChIKey | YMDXZJFXQJVXBF-STHAYSLISA-N |
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| SMILES | CC1OC1P(=O)(O)O |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- SZ7890000
- CHEMICAL NAME :
- Phosphonic acid, (1,2-epoxypropyl)-, (1R,2S)-(-)-
- CAS REGISTRY NUMBER :
- 23155-02-4
- BEILSTEIN REFERENCE NO. :
- 1680831
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C3-H7-O4-P
- MOLECULAR WEIGHT :
- 138.07
- WISWESSER LINE NOTATION :
- T3OTJ BPQQO C1
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA - TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Microorganism - not otherwise specified
- DOSE/DURATION :
- 10 gm/L
- REFERENCE :
- MILEDM Microbios Letters. (Faculty Press, 88 Regent St., Cambridge, UK) V.1- 1976- Volume(issue)/page/year: 8,27,1978
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Safety Information
Customs
| HS Code | 2931900090 |
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| Summary | 2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
| Veramina |
| MFCD00242804 |
| Fosfocina |
| [(2R,3S)-3-methyloxiran-2-yl]phosphonic acid |
| phosphomycin |
| Fosfomycinum |
| FOSFOMYCIN |
| Fosfomicina |
| EINECS 245-463-1 |
| Phosphonomycin |
| Fosfomycine |
