CAS 609799-22-6|Tasimelteon

Introduction：Basic information about CAS 609799-22-6|Tasimelteon, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Tasimelteon BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Tasimelteon
CAS Number	609799-22-6	Molecular Weight	245.317
Density	1.1±0.1 g/cm3	Boiling Point	442.6±24.0 °C at 760 mmHg
Molecular Formula	C₁₅H₁₉NO₂	Melting Point	78°C(lit.)
MSDS	/	Flash Point	221.4±22.9 °C

Names

Name	tasimelteon
Synonym	More Synonyms

Tasimelteon BiologicalActivity

Description	Tasimelteon is a melatonin MT1 and MT2 receptor agonist.Target: melatonin receptorTasimelteon is a novel circadian regulator, is the first product for the treatment of Non-24-hour Sleep-Wake Disorder (Non-24) approved by either the FDA or the European Medicines Agency (EMA). Tasimelteon is a potent and specific melatonin (MT1 and MT2) receptor agonist with 2 - 4 times greater affinity for the MT2 receptor.
Related Catalog	Signaling Pathways >>GPCR/G Protein >>Melatonin ReceptorSignaling Pathways >>Neuronal Signaling >>Melatonin ReceptorResearch Areas >>Neurological Disease
References	[1]. Leger D, et al. Safety profile of tasimelteon, a melatonin MT1 and MT2 receptor agonist: pooled safety analyses from six clinical studies. Expert Opin Drug Saf. 2015;14(11):1673-85. [2]. Keating GM, et al. Tasimelteon: A Review in Non-24-Hour Sleep-Wake Disorder in Totally Blind Individuals. CNS Drugs. 2016 Mar 22.

Description

Tasimelteon is a melatonin MT1 and MT2 receptor agonist.Target: melatonin receptorTasimelteon is a novel circadian regulator, is the first product for the treatment of Non-24-hour Sleep-Wake Disorder (Non-24) approved by either the FDA or the European Medicines Agency (EMA). Tasimelteon is a potent and specific melatonin (MT1 and MT2) receptor agonist with 2 - 4 times greater affinity for the MT2 receptor.

Related Catalog

Signaling Pathways >>GPCR/G Protein >>Melatonin ReceptorSignaling Pathways >>Neuronal Signaling >>Melatonin ReceptorResearch Areas >>Neurological Disease

References

[1]. Leger D, et al. Safety profile of tasimelteon, a melatonin MT1 and MT2 receptor agonist: pooled safety analyses from six clinical studies. Expert Opin Drug Saf. 2015;14(11):1673-85.

[2]. Keating GM, et al. Tasimelteon: A Review in Non-24-Hour Sleep-Wake Disorder in Totally Blind Individuals. CNS Drugs. 2016 Mar 22.

Chemical & Physical Properties

Density	1.1±0.1 g/cm3
Boiling Point	442.6±24.0 °C at 760 mmHg
Melting Point	78°C(lit.)
Molecular Formula	C₁₅H₁₉NO₂
Molecular Weight	245.317
Flash Point	221.4±22.9 °C
Exact Mass	245.141586
PSA	38.33000
LogP	1.75
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.564
InChIKey	PTOIAAWZLUQTIO-GXFFZTMASA-N
SMILES	CCC(=O)NCC1CC1c1cccc2c1CCO2
Storage condition	2-8°C

Synonyms

Hetlioz

Tasimelteon

MA 1

N-[[(1R,2R)-2-(2,3-dihydro-1-benzofuran-4-yl)cyclopropyl]methyl]propanamide

UNII-SHS4PU80D9

Propanamide, N-[[(1R,2R)-2-(2,3-dihydro-4-benzofuranyl)cyclopropyl]methyl]-

N-{[(1R,2R)-2-(2,3-Dihydro-1-benzofuran-4-yl)cyclopropyl]methyl}propanamide

VEC-162

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