CAS 301-19-9|Robinin

Introduction：Basic information about CAS 301-19-9|Robinin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Robinin BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
5. Safety Information
6. Articles10
7. Synonyms

Common Name	Robinin
CAS Number	301-19-9	Molecular Weight	740.659
Density	1.7±0.1 g/cm3	Boiling Point	1064.4±65.0 °C at 760 mmHg
Molecular Formula	C₃₃H₄₀O₁₉	Melting Point	194-195ºC
MSDS	ChineseUSA	Flash Point	335.7±27.8 °C

Names

Name	robinin
Synonym	More Synonyms

Robinin BiologicalActivity

Description	Robinin is present in flavonoid fraction of Vigna unguiculata leaf. Robinin inhibits upregulated expression of TLR2 and TLR4. Robinin ameliorates oxidized low density lipoprotein (Ox-LDL) induced inflammatory insult through TLR4/NF-κB pathway[1].
Related Catalog	Signaling Pathways >>Immunology/Inflammation >>Toll-like Receptor (TLR)Research Areas >>Inflammation/Immunology
Target	TLR2 TLR4
References	[1]. Janeesh PA, et al. Robinin modulates TLR/NF-κB signaling pathway in oxidized LDL induced human peripheral blood mononuclear cells. Int Immunopharmacol. 2014 Jan;18(1):191-7.

Chemical & Physical Properties

Density	1.7±0.1 g/cm3
Boiling Point	1064.4±65.0 °C at 760 mmHg
Melting Point	194-195ºC
Molecular Formula	C₃₃H₄₀O₁₉
Molecular Weight	740.659
Flash Point	335.7±27.8 °C
Exact Mass	740.216370
PSA	308.12000
LogP	0.89
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.728
InChIKey	PEFASEPMJYRQBW-HKWQTAEVSA-N
SMILES	CC1OC(OCC2OC(Oc3c(-c4ccc(O)cc4)oc4cc(OC5OC(C)C(O)C(O)C5O)cc(O)c4c3=O)C(O)C(O)C2O)C(O)C(O)C1O
Storage condition	?20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ2979380

CHEMICAL NAME :: 4H-1-Benzopyran-4-one, 3-((6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-galac topyranosyl) oxy)-7-((6-deoxy-alpha-L-mannopyranosyl)oxy)-5-hydrox y-2-(4-hydroxyphenyl)-

CAS REGISTRY NUMBER :: 301-19-9

LAST UPDATED :: 199410

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C33-H40-O19

MOLECULAR WEIGHT :: 740.73

WISWESSER LINE NOTATION :: T66 BO EVT&J GQ IO- BT6OTJ CQ DQ EQ F1& DO- BT6OTJ CQ DQ EQ F1O- BT6OTJ CQ DQ EQ F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 100 ug/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 66,223,1979

Safety Information

Hazard Codes	Xi
Safety Phrases	22-24/25
RIDADR	NONH for all modes of transport

Articles10

Roles of flavonoids in plant resistance to insects.

Prog. Clin. Biol. Res. 213 , 87-100, (1986)

Simultaneous determination of the flavonoids robinin and kaempferol in human breast cancer cells by liquid chromatography-tandem mass spectrometry.

J. Pharm. Biomed. Anal. 55 , 109-113, (2011)

An accurate, precise and sensitive method was developed and validated for the simultaneous quantification of the flavonoid glycoside robinin, and its algycone kaempferol in human breast cancer MCF-7 c...

Effects of selected flavonoids and carotenoids on drug accumulation and apoptosis induction in multidrug-resistant colon cancer cells expressing MDR1/LRP.

In Vivo 19 , 433-8., (2005)

The effects of various flavonoids and carotenoids on Rhodamine 123 accumulation in multidrug-resistant Colo 320 human colon cancer cells expressing MDR1/LRP were studied. The Colo 205 cell line was us...

Synonyms

4H-1-Benzopyran-4-one, 3-[[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-galactopyranosyl]-oxy]-7-[(6-deoxy-α-L-mannopyranosyl)oxy]-5-hydroxy-2-(4-hydroxyphenyl)-

5-Hydroxy-2-(4-hydroxyphenyl)-7-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-3-{[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-({[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}methyl)tetrahydro-2H-pyran-2-yl]oxy}-4H-chromen-4-one

3-[[6-O-(6-Deoxy-a-L-mannopyranosyl)-b-D-galactopyranosyl]oxy]-7-[(6-deoxy-a-L-mannopyranosyl)oxy]-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

7-[(6-Deoxy-α-L-mannopyranosyl)oxy]-5-hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl-6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-galactopyranoside

kaempherol-3-O-robinoside-7-O-rhamnoside

Kaempferol-3-O-gal-rham-7-O-rham

7-[(6-Deoxy-α-L-mannopyranosyl)oxy]-5-hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl 6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-galactopyranoside

Robinin

5-hydroxy-2-(4-hydroxyphenyl)-7-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-3-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-[[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one

Kaempferol 3-Robinoside 7-Rhamnoside

kaempherol-3-O-gal-rha-7-O-rha

4H-1-Benzopyran-4-one, 3-[[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-galactopyranosyl]oxy]-7-[(6-deoxy-α-L-mannopyranosyl)oxy]-5-hydroxy-2-(4-hydroxyphenyl)-

5-Hydroxy-2-(4-hydroxyphényl)-7-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-méthyltétrahydro-2H-pyran-2-yl]oxy}-3-{[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-({[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-méthyltétrahydro-2H-pyran-2-yl]oxy}méthyl)tétrahydro-2H-pyran-2-yl]oxy}-4H-chromén-4-one

4H-1-Benzopyran-4-one, 3-((6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-galactopyranosyl)oxy)-7-((6-deoxy-α-L-mannopyranosyl)oxy)-5-hydroxy-2-(4-hydroxyphenyl

Kaempferol-3-O-robinoside-7-O-rhamnoside

4H-1-Benzopyran-4-one, 3-((6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-galactopyranosyl)oxy)-7-((6-deoxy-α-L-mannopyranosyl)oxy)-5-hydroxy-2-(4-hydroxyphenyl)-

EINECS 206-113-3

Recommended......