CAS 1085412-37-8|Pyridostatin
Introduction：Basic information about CAS 1085412-37-8|Pyridostatin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Pyridostatin | ||
|---|---|---|---|
| CAS Number | 1085412-37-8 | Molecular Weight | 596.636 |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 753.8±60.0 °C at 760 mmHg |
| Molecular Formula | C31H32N8O5 | Melting Point | / |
| MSDS | USA | Flash Point | 409.7±32.9 °C |
Names
| Name | Pyridostatin |
|---|---|
| Synonym | More Synonyms |
Pyridostatin BiologicalActivity
| Description | Pyridostatin is a G-quadruplexe stabilizer, with a Kd of 490 nM. |
|---|---|
| Related Catalog | Signaling Pathways >>Cell Cycle/DNA Damage >>G-quadruplexResearch Areas >>Cancer |
| Target | Kd: 490 nM (G-quadruplexe)[1] |
| In Vitro | Pyridostatin is a G-quadruplexe stabilizer, with a Kd of 490 nM[1]. Pyridostatin (PDS) shows neurotoxic activity against primary cortical neurons at 0.01-5 μM, causes DNA double-strand breaks (DSBs) at 1 μM, downregulates BRCA1 in neurons at 1, 2 or 5 μM[2]. Pyridostatin interacts with G-quadruplex motifs in SRC and alters mRNA levels of damaged genes[3]. |
| Cell Assay | Cells are plated at equal confluence and either untreated or treated with 2 μM Pyridostatin continually for 72 h. Cells from individual plates are trypsinized and counted in a Coultercounter. Graphs represent total cell numbers at each time interval and error bars represent S.E.M. Data represent three independent experiments[3]. |
| References | [1]. Koirala D, et al. A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands. Nat Chem. 2011 Aug 28;3(10):782-7. [2]. Moruno-Manchon JF, et al. The G-quadruplex DNA stabilizing drug pyridostatin promotes DNA damage and downregulates transcription of Brca1 in neurons. Aging (Albany NY). 2017 Sep 12;9(9):1957-1970. [3]. Rodriguez R, et al. Small-molecule-induced DNA damage identifies alternative DNA structures in human genes. Nat Chem Biol. 2012 Feb 5;8(3):301-10. |
Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 753.8±60.0 °C at 760 mmHg |
| Molecular Formula | C31H32N8O5 |
| Molecular Weight | 596.636 |
| Flash Point | 409.7±32.9 °C |
| Exact Mass | 596.249573 |
| PSA | 202.62000 |
| LogP | 0.59 |
| Vapour Pressure | 0.0±2.5 mmHg at 25°C |
| Index of Refraction | 1.726 |
| InChIKey | VGHSATQVJCTKEF-UHFFFAOYSA-N |
| SMILES | NCCOc1cc(C(=O)Nc2cc(OCCN)c3ccccc3n2)nc(C(=O)Nc2cc(OCCN)c3ccccc3n2)c1 |
Synonyms
| 2,6-Pyridinedicarboxamide, 4-(2-aminoethoxy)-N,N-bis[4-(2-aminoethoxy)-2-quinolinyl]- |
| 4-(2-Aminoethoxy)-N,N'-bis[4-(2-aminoethoxy)-2-quinolinyl]-2,6-pyridinedicarboxamide |
| RR82 |
| Pyridostatin |
| Pyridostatin trifluoroacetate salt |
