Introduction：Basic information about CAS 1448428-04-3|Selonsertib(GS-4997), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Selonsertib(GS-4997) |
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| CAS Number | 1448428-04-3 | Molecular Weight | 445.492 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C24H24FN7O | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | Selonsertib |
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| Synonym | More Synonyms |
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Selonsertib(GS-4997) BiologicalActivity
| Description | Selonsertib is an apoptosis signal-regulating kinase 1 (ASK1) inhibitor with a pIC50 of 8.3±0.07. |
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| Related Catalog | Signaling Pathways >>MAPK/ERK Pathway >>MAP3KResearch Areas >>Cancer |
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| Target | ASK1:8.3 (pIC50) |
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| In Vitro | Selonsertib (GS-4997) is a clinical stage ASK1 inhibitor, which has been evaluated as an experimental treatment for diabetic nephropathy and kidney fibrosis[1]. Selonsertib (GS-4997) is a highly selective and potent once-daily oral ASK1 inhibitor that competes with ATP in the ASK1 catalytic kinase domain[2]. |
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| References | [1]. Lanier M, et al. Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure. ACS Med Chem Lett. 2017 Feb 8;8(3):316-320. [2]. Lin JH, et al. Design of a phase 2 clinical trial of an ASK1 inhibitor, GS-4997, in patients with diabetic kidney disease. Nephron. 2015;129(1):29-33. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Molecular Formula | C24H24FN7O |
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| Molecular Weight | 445.492 |
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| Exact Mass | 445.202637 |
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| LogP | 3.17 |
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| Index of Refraction | 1.704 |
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| InChIKey | YIDDLAAKOYYGJG-UHFFFAOYSA-N |
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| SMILES | Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1 |
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| Storage condition | -20℃ |
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Synonyms
| selonsertib |
| Benzamide, 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-methyl-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]- |
| UNII:NS3988A2TC |
| 5-(4-Cyclopropyl-1H-imidazol-1-yl)-2-fluoro-N-[6-(4-isopropyl-4H-1,2,4-triazol-3-yl)-2-pyridinyl]-4-methylbenzamide |
| GS-4997 |
