CAS 1450655-76-1|CPI-169

Introduction：Basic information about CAS 1450655-76-1|CPI-169, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. CPI-169 BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	CPI-169
CAS Number	1450655-76-1	Molecular Weight	528.664
Density	1.3±0.1 g/cm3	Boiling Point	/
Molecular Formula	C₂₇H₃₆N₄O₅S	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	1-(1-(1-(ethylsulfonyl)piperidin-4-yl)ethyl)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2- methyl-1H-indole-3-carboxamide
Synonym	More Synonyms

CPI-169 BiologicalActivity

Description	CPI-169 racemate is the racemate of CPI-169. CPI-169 is a novel and potent EZH2 inhibitor.
Related Catalog	Signaling Pathways >>Epigenetics >>Epigenetic Reader DomainResearch Areas >>Cancer
References	[1]. Vidya Balasubramanian, et al. CPI-169, a novel and potent EZH2 inhibitor, synergizes with CHOP in vivoand achieves complete regression in lymphoma xenograft models. Cancer Res October 1, 2014 74; 1697 [2]. Bradley WD, et al. EZH2 inhibitor efficacy in non-Hodgkin's lymphoma does not require suppression of H3K27 monomethylation. Chem Biol. 2014 Nov 20;21(11):1463-75.

Description

CPI-169 racemate is the racemate of CPI-169. CPI-169 is a novel and potent EZH2 inhibitor.

Related Catalog

Signaling Pathways >>Epigenetics >>Epigenetic Reader DomainResearch Areas >>Cancer

References

[1]. Vidya Balasubramanian, et al. CPI-169, a novel and potent EZH2 inhibitor, synergizes with CHOP in vivoand achieves complete regression in lymphoma xenograft models. Cancer Res October 1, 2014 74; 1697

[2]. Bradley WD, et al. EZH2 inhibitor efficacy in non-Hodgkin's lymphoma does not require suppression of H3K27 monomethylation. Chem Biol. 2014 Nov 20;21(11):1463-75.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Molecular Formula	C₂₇H₃₆N₄O₅S
Molecular Weight	528.664
Exact Mass	528.240662
PSA	121.88000
LogP	2.67
Index of Refraction	1.631
InChIKey	LHGUZCKPFXXVPV-UHFFFAOYSA-N
SMILES	CCS(=O)(=O)N1CCC(C(C)n2c(C)c(C(=O)NCc3c(OC)cc(C)[nH]c3=O)c3ccccc32)CC1
Storage condition	-20℃

Synonyms

1-(1-(1-(ethylsulfonyl)piperidin-4-yl)ethyl)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1H-indole-3-carboxamide

1-{(1R)-1-[1-(Ethylsulfonyl)-4-piperidinyl]ethyl}-N-[(4-methoxy-6-methyl-2-oxo-1,2-dihydro-3-pyridinyl)methyl]-2-methyl-1H-indole-3-carboxamide

CPI-169

1H-Indole-3-carboxamide, N-[(1,2-dihydro-4-methoxy-6-methyl-2-oxo-3-pyridinyl)methyl]-1-[(1R)-1-[1-(ethylsulfonyl)-4-piperidinyl]ethyl]-2-methyl-

CPI-169 racemate

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