Introduction：Basic information about CAS 1029044-16-3|Pexidartinib, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Pexidartinib |
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| CAS Number | 1029044-16-3 | Molecular Weight | 417.815 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | 580.0±50.0 °C at 760 mmHg |
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| Molecular Formula | C20H15ClF3N5 | Melting Point | / |
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| MSDS | / | Flash Point | 304.6±30.1 °C |
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Names
| Name | Pexidartinib |
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| Synonym | More Synonyms |
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Pexidartinib BiologicalActivity
| Description | Pexidartinib (PLX-3397) is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 13 nM, 27 nM, and 11 nM for CSF1R, c-Kit, and FLT3, respectively. |
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| Related Catalog | Signaling Pathways >>Protein Tyrosine Kinase/RTK >>c-FmsSignaling Pathways >>Protein Tyrosine Kinase/RTK >>c-KitResearch Areas >>Cancer |
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| Target | IC50: 28 nM (c-Fms), 16 nM (c-Kit) |
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| In Vivo | Pexidartinib is a potent drug for treatment of cancer and used for Phase III TGCT clinical trial[1]. |
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| References | [1]. Gelhorn HL, et al. Patient-reported Symptoms of Tenosynovial Giant Cell Tumors. Clin Ther. 2016 Apr;38(4):778-93. |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Boiling Point | 580.0±50.0 °C at 760 mmHg |
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| Molecular Formula | C20H15ClF3N5 |
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| Molecular Weight | 417.815 |
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| Flash Point | 304.6±30.1 °C |
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| Exact Mass | 417.096802 |
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| PSA | 66.49000 |
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| LogP | 4.77 |
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| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
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| Index of Refraction | 1.662 |
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| InChIKey | JGWRKYUXBBNENE-UHFFFAOYSA-N |
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| SMILES | FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1 |
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| Storage condition | -20℃ |
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Safety Information
Synonyms
| PLX3397 |
| 5-[(5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-N-{[6-(trifluoromethyl)-3-pyridinyl]methyl}-2-pyridinamine |
| 3-Pyridinemethanamine, N-[5-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-6-(trifluoromethyl)- |
| N-[5-[(5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-6-(trifluoromethyl)-3-pyridinemethanamine |
| PLX-3397 |
| pexidartinib |
