CAS 9039-53-6|Urokinase
| Common Name | Urokinase | ||
|---|---|---|---|
| CAS Number | 9039-53-6 | Molecular Weight | / |
| Density | / | Boiling Point | / |
| Molecular Formula | C21H25BrN2O3 | Melting Point | / |
| MSDS | USA | Flash Point | / |
Names
| Name | Urokinase |
|---|---|
| Synonym | More Synonyms |
Urokinase BiologicalActivity
| Description | Urokinase peptidolytic (Urokinase-type plasminogen activator) is a serine protease, an inactive form (zymogen) of the serine protease plasminogen. Activation of plasmin triggers a proteolytic cascade reaction, which in turn participates in thrombolysis or extracellular matrix degradation, implicated in vascular disease and cancer-related research[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>Ser/Thr ProteaseResearch Areas >>CancerResearch Areas >>Cardiovascular Disease |
| In Vitro | Urokinase peptidolytic(uPA) 在非小细胞肺癌 (NSCLC) 中能够增加 uPAR 蛋白质和 mRNA 水平的表达[1]。 |
| References | [1]. Nunzia Montuori, et al. Urokinase-mediated posttranscriptional regulation of urokinase-receptor expression in non small cell lung carcinoma. Int J Cancer. 2003 Jun 20;105(3):353-60 |
Chemical & Physical Properties
| Molecular Formula | C21H25BrN2O3 |
|---|---|
| Appearance of Characters | powder | white |
| Storage condition | 2-8°C |
| Water Solubility | Soluble in water. | Reconstitute in water at 100µg/ml |
Safety Information
| Hazard Codes | B |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | OB8900000 |
Articles87
More Articles| Hepatic stellate cells orchestrate clearance of necrotic cells in a hypoxia-inducible factor-1α-dependent manner by modulating macrophage phenotype in mice. J. Immunol. 192(8) , 3847-57, (2014) Hypoxia-inducible factor-1α (HIF-1α) is activated in hepatic stellate cells (HSCs) by hypoxia and regulates genes important for tissue repair. Whether HIF-1α is activated in HSCs after acute injury an... | |
| Tissue-type plasminogen activator deficiency delays bone repair: roles of osteoblastic proliferation and vascular endothelial growth factor. Am. J. Physiol. Endocrinol. Metab. 307(3) , E278-88, (2014) Further development in research of bone regeneration is necessary to meet the clinical demand for bone reconstruction. Recently, we reported that plasminogen is crucial for bone repair through enhance... | |
| Endocrine regulation of airway contractility is overlooked. J. Endocrinol. 222(2) , R61-73, (2014) Asthma is a prevalent respiratory disorder triggered by a variety of inhaled environmental factors, such as allergens, viruses, and pollutants. Asthma is characterized by an elevated activation of the... |
Synonyms
| urokinase, high mw (urine) |
| ec 3.4.99.26 |
| urokinase, low mw (urine) |
| urokinase |
| urokinase upa 2-chain |
| urokinase, high molecular weight |
| urokinase 2-chain |
| MFCD00132566 |
| urokinase (mixed) |
