CAS 9026-93-1|Native Calf Adenosine Deaminase
| Common Name | Native Calf Adenosine Deaminase | ||
|---|---|---|---|
| CAS Number | 9026-93-1 | Molecular Weight | / |
| Density | / | Boiling Point | / |
| Molecular Formula | / | Melting Point | / |
| MSDS | USA | Flash Point | / |
Names
| Name | Adenosine deaminase |
|---|---|
| Synonym | More Synonyms |
Native Calf Adenosine Deaminase BiologicalActivity
| Description | Adenosine deaminase is an enzyme that catalyzes the irreversible deamination of adenosine and 2'-deoxyadenosine to inosine and 2'-deoxyinosine, respectively. |
|---|---|
| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>Adenosine DeaminaseResearch Areas >>Inflammation/Immunology |
| In Vitro | Adenosine deaminase (ADA; EC 3.5.4.4) catalyzes the irreversible deamination of adenosine and 2′-deoxyadenosine to inosine and 2′-deoxyinosine, respectively. Adenosine deaminase is implicated in purine metabolism and distributed in most mammalian tissues. Genetic Adenosine deaminase deficiency results in lymphopenia and severe combined immunodeficiency disease by decreasing the differentiation and maturation of lymphoid cells[1]. Adenosine deaminase is a signaling molecule related to the activation of T lympho-cytes, making it a useful inflammation marker, especially for menin-gitis and tuberculous pleuritis[2]. |
| References | [1]. Tian X, et al. Probing inhibition mechanisms of adenosine deaminase by using molecular dynamics simulations. PLoS One. 2018 Nov 16;13(11):e0207234. [2]. Silva Dalsasso Joaquim L, et al. Analytical validation of an in-house method for adenosine deaminase determination. J Clin Lab Anal. 2018 Nov 29:e22823. |
Chemical & Physical Properties
| InChIKey | XKSKQIORVXERAQ-UHFFFAOYSA-O |
|---|---|
| SMILES | CCCCCCCCCCC=CCCCCCCCCCCCCCCCCCCCC(=O)OC(COC(=O)CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC)COP(=O)(O)OCC[N+](C)(C)C |
| Storage condition | 2-8C |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US) |
|---|---|
| RIDADR | NONH for all modes of transport |
Articles57
More Articles| Ecto-5'-nucleotidase, CD73, is an endothelium-derived hyperpolarizing factor synthase. Arterioscler. Thromb. Vasc. Biol. 33(3) , 629-36, (2013) Adenosine dilates human coronary arteries by activating potassium channels in an endothelial cell-independent manner. Cell surface ecto-5'-nucleotidase (CD73) rapidly dephosphorylates extracellular ad... | |
| Ectoenzymes and cholinesterase activity and biomarkers of oxidative stress in patients with lung cancer. Mol. Cell Biochem. 374(1-2) , 137-48, (2013) We aimed to examine the nucleoside triphosphate diphosphohydrolases (NTPDase) in lymphocytes; adenosine deaminase (ADA) and butyrylcholinesterase (BChE) in serum; and acetylcholinesterase (AChE), supe... | |
| Acute effect of β-sitosterol on calcium uptake mediates anti-inflammatory effect in murine activated neutrophils. J. Pharm. Pharmacol. 65(1) , 115-22, (2013) To evaluate the effect of β-sitosterol on ⁴⁵Ca²⁺ uptake in activated murine neutrophils, and upon myeloperoxidase and adenosine deaminase activity, and interleukin-1β (IL-1β) and tumour necrosis facto... |
Synonyms
| adenosine deaminase type viii |
| adenosine deaminase type ix |
| MFCD00081287 |
| human adenosine deaminase |
| adenosine deaminase |
| adenosine deaminase, bovine intestine |
| ec 3.5.4.4 |
| adenosine deaminase type v |
| Native Calf Adenosine Deaminase |
