CAS 9028-56-2|3alpha-hydroxysteroid dehydrogenase
| Common Name | 3alpha-hydroxysteroid dehydrogenase | ||
|---|---|---|---|
| CAS Number | 9028-56-2 | Molecular Weight | / |
| Density | / | Boiling Point | / |
| Molecular Formula | / | Melting Point | / |
| MSDS | USA | Flash Point | / |
Names
| Name | Dehydrogenase 3alpha-hydroxy steroid |
|---|---|
| Synonym | More Synonyms |
3alpha-hydroxysteroid dehydrogenase BiologicalActivity
| Description | 3α-Hydroxysteroid dehydrogenase (3α-HSD) is an enzyme encoded by the AKR1C4 gene, which can catalyze the conversion of 3-ketosteroids into 3α-hydroxy compounds. 3α-Hydroxysteroid dehydrogenase plays an important role in the inactivation of androgen DHT, and can convert DHT into 3α-androstanediol with weak androgen activity, which can be used in the research of hirsutism[1]. |
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| Related Catalog | Research Areas >>Endocrinology |
| References | [1]. Anne Z Steiner, et al. 3alpha-Hydroxysteroid dehydrogenase type III deficiency: a novel mechanism for hirsutism. J Clin Endocrinol Metab. 2008 Apr;93(4):1298-303. |
Chemical & Physical Properties
| Appearance of Characters | ammonium sulfate suspension |
|---|---|
| InChIKey | WZWONBSCKCYGIW-UHFFFAOYSA-N |
| SMILES | O=C1C(=O)c2ccccc2C1=Cc1cc2c(s1)C1=CC3C=C4C(=CC3C=C1C21CCCCC1)c1sc(C=C2C(=O)C(=O)c3ccccc32)cc1C41CCCCC1 |
| Storage condition | 2-8°C |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | 24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles29
More Articles| Electronic effects of para-substitution on acetophenones in the reaction of rat liver 3alpha-hydroxysteroid dehydrogenase. Bioorg. Med. Chem. 16 , 1084-9, (2008) Stereoselective reductive metabolism of various p-substituted acetophenone derivatives was studied using isolated rat liver 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD). Kinetic experiments were p... | |
| Enzyme biosensor for androsterone based on 3α-hydroxysteroid dehydrogenase immobilized onto a carbon nanotubes/ionic liquid/NAD+ composite electrode. Talanta 99 , 697-702, (2012) A 3α-hydrosteroid biosensor for androsterone determination has been prepared by immobilizing the enzyme 3α-hydroxysteroid dehydrogenase (3α-HSD) in a composite electrode platform constituted of a mixt... | |
| Prostaglandin dehydrogenase activity of purified rat liver 3 alpha-hydroxysteroid dehydrogenase. Biochem. Biophys. Res. Commun. 148(2) , 646-52, (1987) Homogeneous 3 alpha-hydroxysteroid dehydrogenase (3 alpha-HSD) from rat liver cytosol displays 9, 11, and 15-hydroxyprostaglandin dehydrogenase activity. Using [14C]-PGF2 alpha as substrate the produc... |
Synonyms
| ALPHA-HYDROXYSTEROID DEHYDROGENASE |
| 3ALPHA-HYDROXYSTEROID: NAD[P]+ OXIDOREDUCTASE |
| EC 1.1.1.50 |
| EC: 1.1.1.50 |
| 3alpha-hydroxysteroid dehydrogenase F. pseu. test. ~9 U/mg |
| 3alpha-Hydroxysteroid Dehydrogenase from Pseudomonas testosteroni |
| Dehydrogenase, 3alpha-hydroxy steroid |
