Introduction：Basic information about CAS 320725-47-1|squalamine lactate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | squalamine lactate |
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| CAS Number | 320725-47-1 | Molecular Weight | 736.055 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C37H71N3O8S | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 1-(Diphenylmethyl)hydrazine hydrochloride |
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| Synonym | More Synonyms |
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squalamine lactate BiologicalActivity
| Description | Squalamine lactate is an aminosterol compound discovered in the tissues of the dogfish shark, with antimicrobial activity, and used for the treatment of neovascular age-related macular degeneration. |
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| Related Catalog | Signaling Pathways >>Anti-infection >>BacterialNatural Products >>OthersResearch Areas >>Cardiovascular DiseaseResearch Areas >>Infection |
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| In Vitro | Squalamine lactate has a more generalized effect on the cellular signaling cascade that is common to both VEGF and other growth factors[1]. Squalamine blocks the action of VEGF and integrin expression, thereby inhibiting angiogenesis, when bound to calmodulin[2]. |
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| In Vivo | Squalamine is ineffective when administered intravitreally and therefore requires intravenous dosing. However, systemic dosing has yielded promising results in rats as well as humans[2]. |
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| References | [1]. Hussain RM, et al. Emerging vascular endothelial growth factor antagonists to treat neovascular age-related macular degeneration. Expert Opin Emerg Drugs. 2017 Sep;22(3):235-246. [2]. Emerson MV, et al. Current and emerging therapies for the treatment of age-related macular degeneration. Clin Ophthalmol. 2008 Jun;2(2):377-88. |
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Chemical & Physical Properties
| Molecular Formula | C37H71N3O8S |
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| Molecular Weight | 736.055 |
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| Exact Mass | 735.506775 |
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| InChIKey | JMNXSNUXDHHTKQ-QVMSTPCGSA-N |
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| SMILES | CC(C)C(CCC(C)C1CCC2C3C(O)CC4CC(NCCCNCCCCN)CCC4(C)C3CCC12C)OS(=O)(=O)O.CC(O)C(=O)O |
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| Storage condition | -20°C |
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Synonyms
| (2S)-2-Hydroxypropanoic acid - (3β,5α,7α,24R)-3-({3-[(4-aminobutyl)amino]propyl}amino)-7-hydroxycholestan-24-yl hydrogen sulfate hydrate (1:1:1) |
| squalamine lactate |
