CAS 9003-98-9|Deoxyribonuclease
Introduction：Basic information about CAS 9003-98-9|Deoxyribonuclease, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Deoxyribonuclease | ||
|---|---|---|---|
| CAS Number | 9003-98-9 | Molecular Weight | / |
| Density | 100 g/mL at 20 °C | Boiling Point | / |
| Molecular Formula | / | Melting Point | / |
| MSDS | USA | Flash Point | / |
Names
| Name | Deoxyribonuclease |
|---|---|
| Synonym | More Synonyms |
Deoxyribonuclease BiologicalActivity
| Description | Deoxyribonuclease (DNase) is an enzyme that degrade DNA, it plays a key role in the cleavage of extracellular DNA is crucial for limiting the inflammatory response and maintaining homeostasis. Exogenous deoxyribonuclease shows beneficial effects in inflammatory diseases and cancer[1]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology |
| In Vivo | Deoxyribonuclease (0.1 U; i.p.; once daily for 3 days) inhibits liver metastasis, besides results in a greater prolongation of the survival period by combining surgical removal of the primary tumour mass[1]. Animal Model: Female BALB/c x DBA/2 mice with murine tumour L5178Y-ML cells subcutaneous injection[1] Dosage: 0.1 U per mouse Administration: Intravenous injection; 0.1 U; once daily for three days Result: Reduced liver weight from 2.26 to 1.55 g, affected the intensity of liver metastasis, reduced the numbers and sizes of metastatic and affected tumour cell arrest. Animal Model: Female BALB/c x DBA/2 mice with murine tumour and surgical removal of subcutaneous tumours[1] Dosage: 0.1 U per mouse Administration: Intravenous injection; 0.1 U; once daily for 3 days either before or after primary tumour removal Result: Significantly prolongated survival after tumour cell inoculation compared to the untreated group. |
Chemical & Physical Properties
| Density | 100 g/mL at 20 °C |
|---|---|
| Appearance of Characters | solution (clear, colorless) | white |
| Storage condition | −20°C |
| Water Solubility | Soluble in 0.15 M sodium chloride (5.0mg/L) clear. |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | 23-24/25-22 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | RF0750000 |
Articles123
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| Mitochondrial damage contributes to Pseudomonas aeruginosa activation of the inflammasome and is downregulated by autophagy. Autophagy 11(1) , 166-82, (2015) The nucleotide-binding domain, leucine-rich repeat containing family caspase recruitment domain containing 4 (NLRC4) inflammasome can be activated by pathogenic bacteria via products translocated thro... |
Synonyms
| Alkaline DNase |
| Alkaline deoxyribonuclease |
| DNA depolymerase |
| DNA endonuclease |
| DNA nuclease |
| DNAase |
| DNase |
| Deoxyribonuclease A |
| Deoxyribonuclease I |
| Deoxyribonucleic phosphatase |
| Desoxyribonuclease |
| Dornase |
| Pancreatic deoxyribonuclease |
| Pancreatic dornase |
