CAS 86784-80-7|Corticotropin-Releasing Factor, human, rat
| Common Name | Corticotropin-Releasing Factor, human, rat | ||
|---|---|---|---|
| CAS Number | 86784-80-7 | Molecular Weight | 4757.45 |
| Density | / | Boiling Point | / |
| Molecular Formula | C208H344N60O63S2 | Melting Point | / |
| MSDS | USA | Flash Point | / |
Names
| Name | Corticotropin-releasing factor (human and rat) |
|---|---|
| Synonym | More Synonyms |
BiologicalActivity
| Description | Corticotropin-releasing factor (CRF) (human) stimulates the synthesis and secretion of adrenocorticotropin in the anterior pituitary. Sequence: Ser-Glu-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Met-Glu-Ile-Ile-NH2. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Neurological DiseasePeptides |
| In Vitro | CRF increases excitability of type II dlBNST neurons through activation of the AC-cAMP-PKA pathway, thereby causing pain-induced aversive responses[1]. |
| In Vivo | The findings are consistent with a mechanism whereby the excess CRF that characterizes stress-related diseases initiates distinct cellular processes in male and female brains, as a result of sex-biased CRF1 signaling[2]. CRF injection on food intake (FI), CRF suppresses FI in 3-month male and female animals[3]. |
| References | [1]. Kaneko T et al. Activation of adenylate cyclase-cyclic AMP-protein kinase A signaling by corticotropin-releasing factorwithin the dorsolateral bed nucleus of the stria terminalis is involved in pain-induced aversion. Eur J Neurosci. 2016 Sep 30. [2]. Bangasser DA et al. Corticotropin-releasing factor overexpression gives rise to sex differences in Alzheimer's disease-related signaling. Mol Psychiatry. 2016 Oct 18. [3]. Tenk J et al. Acute central effects of corticotropin-releasing factor (CRF) on energy balance: Effects of age and gender. Peptides. 2016 Nov;85:63-72. |
Chemical & Physical Properties
| Molecular Formula | C208H344N60O63S2 |
|---|---|
| Molecular Weight | 4757.45 |
| Storage condition | −20°C |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | GM7925000 |
Articles6
More Articles| Effects of corticotrophin releasing hormone (CRH) on cell viability and differentiation in the human BeWo choriocarcinoma cell line: a potential syncytialisation inducer distinct from cyclic adenosine monophosphate (cAMP). Reprod. Biol. Endocrinol. 11 , 30, (2013) Placental production of corticotrophin releasing hormone (CRH) rises exponentially as pregnancy progresses, and has been linked with the onset of normal and preterm labour. CRH is produced in syncytio... | |
| Modulation of Sleep Homeostasis by Corticotropin Releasing Hormone in REM Sleep-Deprived Rats. Int. J. Endocrinol. 2010 , 326151, (2010) Studies have shown that sleep recovery following different protocols of forced waking varies according to the level of stress inherent to each method. Sleep deprivation activates the hypothalamic-pitu... | |
| Identification of a novel interaction between corticotropin releasing hormone (Crh) and macroautophagy. Sci. Rep. 6 , 23342, (2016) In inflammatory bowel disease (IBD), compromised restitution of the epithelial barrier contributes to disease severity. Owing to the complexity in the pathogenesis of IBD, a variety of factors have be... |
Synonyms
| Human corticotropin-releasing hormone-41 |
| Rat/human corticotropin-releasing factor |
| Corticorelin acetate |
| Corticorelin |
| Human CRF(1-41) |
| MFCD00213806 |
| SEEPPISLDLTFHLLREVLEMARAEQLAQQAHSNRKLMEII-NH2 |
| Corticorelin (Human) |
| Corticotropin-releasing factor (human) |
