Introduction：Basic information about CAS 161982-62-3|Depreotide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Depreotide |
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| CAS Number | 161982-62-3 | Molecular Weight | 1357.688 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 1654.2±65.0 °C at 760 mmHg |
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| Molecular Formula | C65H96N16O12S2 | Melting Point | / |
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| MSDS | / | Flash Point | 954.2±34.3 °C |
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Names
| Name | Depreotide |
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| Synonym | More Synonyms |
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Depreotide BiologicalActivity
| Description | Depreotide is a nove tumor tarcer, can be complexed with technetium-99m (99mTc-depreotide) for optimal imaging properties. 99mTc-depreotide somatostain receptor imaging has been playing an important role in medical diagnosis research[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>Others |
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| In Vitro | Depreotide, complexed with technetium-99m to form (99m)Tc-depreotide, binds somatostatin receptors (SSTRs) with high affinity to SSTRs 2, 3, and 5[1]. |
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| In Vivo | 99mTc-depreotide (sodium chloride 0.9% w/v solution; i.v.; single dose) shows a optimal image interpretation with SPECT images (Single Photon Emission Computed Tomography) between 2 and 4 hours following injection[2]. |
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| References | [1]. Rodrigues M, et al. 99mTc-depreotide scintigraphy versus 18F-FDG-PET in the diagnosis of radioiodine-negative thyroid cancer. J Clin Endocrinol Metab. 2006 Oct;91(10):3997-4000. [2]. Halley A, et al. Efficiency of 18F-FDG and 99mTc-depreotide SPECT in the diagnosis of malignancy of solitary pulmonary nodules. Eur J Nucl Med Mol Imaging. 2005 Sep;32(9):1026-32. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 1654.2±65.0 °C at 760 mmHg |
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| Molecular Formula | C65H96N16O12S2 |
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| Molecular Weight | 1357.688 |
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| Flash Point | 954.2±34.3 °C |
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| Exact Mass | 1356.683472 |
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| LogP | -1.03 |
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| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
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| Index of Refraction | 1.582 |
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| InChIKey | XXXSJQLZVNKRKX-YQRDHHIGSA-N |
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| SMILES | CC(C)C1NC(=O)C(CCCCN)NC(=O)C(Cc2c[nH]c3ccccc23)NC(=O)C(Cc2ccc(O)cc2)NC(=O)C(Cc2ccccc2)N(C)C(=O)C(CCSCC(=O)NCC(N)C(=O)NC(CCCCN)C(=O)NC(CS)C(=O)NC(CCCCN)C(N)=O)NC1=O |
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Synonyms
| (2S,5R,8S,11S)-11-Amino-2,8-bis(4-aminobutyl)-18-[(2S,5S,8S,11R,14S,17S)-14-(4-aminobutyl)-5-benzyl-8-(4-hydroxybenzyl)-11-(1H-indol-3-ylmethyl)-17-isopropyl-4-methyl-3,6,9,12,15,18-hexaoxo-1,4,7,10,13,16-hexaazacyclooctadecan-2-yl]-4,7,10,14-tetraoxo-5-(sulfanylmethyl)-16-thia-3,6,9,13-tetraazaoctadecan-1-amide |
| Cyclo(L-homocysteinyl-N-methyl-L-phenylalanyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl) (1®1')-Sulfide with 3-(2-Mercaptoacetamido)-L-alanyl-L-lysyl-L-cysteinyl-L-lysinamide |
| Depreotide |
| Cyclo[S-[(5S,8S,11R,14S)-5,18-diamino-8-(4-aminobutyl)-14-(aminocarbonyl)-11-(mercaptomethyl)-2,6,9,12-tetraoxo-3,7,10,13-tetraazaoctadec-1-yl]-L-homocysteyl-N-methyl-L-phenylalanyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl] |
| NeoTect |
| Cyclo(L-homocysteinyl-N-methyl-L-phenylalanyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl) (1-1')-thioether with 3-[(2-mercaptoacetyl)amino]-L-alanyl-L-lysyl-L-cysteinyl-L-lysinamide |
