Introduction：Basic information about CAS 295350-45-7|H-Pro-Gly-NH2 · HCl, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | H-Pro-Gly-NH2 · HCl |
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| CAS Number | 295350-45-7 | Molecular Weight | 1459.091 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C72H96ClN17O14 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | Ozarelix |
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| Synonym | More Synonyms |
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H-Pro-Gly-NH2 · HCl BiologicalActivity
| Description | Ozarelix (D-63153) is a GnRH antagonist. Ozarelix induces cell apoptosis and arrests cell in G2/M phase. Ozarelix can be used in the research of prostate cancer[1]. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>GNRH ReceptorSignaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Cancer |
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| In Vitro | Ozarelix (0-20 ng/mL, 72 h) inhibits PC3 and DU145 cell proliferation[1]. Ozarelix (0-20 ng/mL, 72 h) induces apoptosis in PC3 and DU145 cells[1]. Ozarelix (20 ng/mL, 72 h) triggers caspase 8-dependent caspase 3 activation[1]. Cell Proliferation Assay[1] Cell Line: Serum-starved PC3 and DU145 cells Concentration: 0, 5, 10, 20 ng/mL Incubation Time: 0, 24, 48, 72, 96 h Result: Inhibited cell proliferation in a dose and time-dependent manner. Western Blot Analysis[1] Cell Line: PC3 and DU145 cells Concentration: 0, 5, 10, 20 ng/mL Incubation Time: 72 h Result: Increased the levels of p21 and p27 both in PC3 and DU145 cells. Decreased levels of anti-apoptotic proteins such as Bcl2 and Bcl-Xl. Upregulated Erk and p38MAPK activity. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Molecular Formula | C72H96ClN17O14 |
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| Molecular Weight | 1459.091 |
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| Exact Mass | 1457.701172 |
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| PSA | 486.88000 |
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| LogP | 3.42 |
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| Index of Refraction | 1.659 |
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| InChIKey | KATZUZNTRINHDT-HALMFYTRSA-N |
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| SMILES | CCCCC(NC(=O)C(CCCCNC(N)=O)NC(=O)C(Cc1ccc(O)cc1)N(C)C(=O)C(CO)NC(=O)C(Cc1cccnc1)NC(=O)C(Cc1ccc(Cl)cc1)NC(=O)C(Cc1ccc2ccccc2c1)NC(C)=O)C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)NC(C)C(N)=O |
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Synonyms
| Ozarelix |
| N-Acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-N-methyl-L-tyrosyl-N6-(aminocarbonyl)-D-lysyl-L-norleucyl-L-arginyl-L-prolyl-D-alaninamide |
| D 63153 |
| D-Alaninamide, N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-N-methyl-L-tyrosyl-N-(aminocarbonyl)-D-lysyl-L-norleucyl-L-arginyl-L-prolyl- |
| D-63153 |
| N-Acetyl-3-(2-naphthyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-N-methyl-L-tyrosyl-N-carbamoyl-D-lysyl-L-norleucyl-L-arginyl-L-prolyl-D-alaninamide |
| UNII-Q1IF8M2YL3 |
