Introduction：Basic information about CAS 508-24-7|Tumulosic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Tumulosic acid |
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| CAS Number | 508-24-7 | Molecular Weight | 486.72600 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C31H50O4 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | Tumulosic acid |
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| Synonym | More Synonyms |
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Tumulosic acid BiologicalActivity
| Description | Tumulosic acid, a triterpenoid, inhibits KLK5 protease activity (IC50= 14.84 μM). Tumulosic acid suppresses the proteolytic processing of LL-37 in keratinocytes at ≤10 μM[1]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology |
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| In Vitro | Tumulosic acid displays dose-dependent anti-KLK5 activity (IC50=19.3 μM)[1]. Tumulosic acid decreases in LL-37 production in human keratinocytes[1]. Tumulosic acid shows IC50 values of 14.84 and 10.48 μM against KLK5 and trypsin proteases, while it exhibited a weak inhibitory effect on KLK7 and chymotrypsin C proteases (19.5% and 4.0%, respectively, at 100 μM)[1]. Western Blot Analysis[1] Cell Line: Normal human epidermal keratinocytes (NHEKs) Concentration: 1 μM and 10 μM Incubation Time: 23 h in the presence of 10 μM cycloheximide Result: Decreased LL-37 production in epidermal keratinocytes. |
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| References | [1]. Matsubara Y, et al. Inhibition of Human Kallikrein 5 Protease by Triterpenoids from Natural Sources. Molecules. 2017;22(11):1829. Published 2017 Oct 27. |
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Chemical & Physical Properties
| Molecular Formula | C31H50O4 |
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| Molecular Weight | 486.72600 |
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| Exact Mass | 486.37100 |
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| PSA | 77.76000 |
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| LogP | 6.76060 |
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| InChIKey | XADJANKGURNTIA-YEXRKOARSA-N |
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| SMILES | C=C(CCC(C(=O)O)C1C(O)CC2(C)C3=C(CCC12C)C1(C)CCC(O)C(C)(C)C1CC3)C(C)C |
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| Storage condition | 2-8℃ |
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Synonyms
| 3β,16α-dihydroxy-eburica-8,24(28)-dien-21-oic acid |
| 3β,16α-Dihydroxy-eburica-8,24(28)-dien-21-saeure |
| 3β.16α-Dihydroxy-24-methylen-lanosten-(8)-saeure-(21) |
| Tumulosaeure |
| Tumulossaeure |
