Introduction：Basic information about CAS 62949-77-3|Kuwanon A, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Kuwanon A |
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| CAS Number | 62949-77-3 | Molecular Weight | 420.45400 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C25H24O6 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | Kuwanon A |
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| Synonym | More Synonyms |
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Kuwanon A BiologicalActivity
| Description | Kuwanon A is a flavone derivative isolated from the root barks of the mulberry tree (Morus alba L.); inhibits nitric oxide production with an IC50 of 10.5 μM. |
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| Related Catalog | Signaling Pathways >>Immunology/Inflammation >>NO SynthaseNatural Products >>FlavonoidsResearch Areas >>Inflammation/ImmunologyResearch Areas >>Metabolic Disease |
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| Target | IC50: 10.5 μM (nitric oxide)[1] |
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| In Vitro | Kuwanon A shows significant inhibitory activity towards the differentiation of 3T3-L1 adipocytes with TG inhibition values of 47.1%. Kuwanon A also shows significant nitric oxide (NO) production inhibitory effects in RAW264.7 cells with an IC50 of 10.5 μM[1]. |
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| Cell Assay | RAW264.7 cells are treated with Kuwanon A (3, 10, 20, 30, 100 μM). Cell viability is measured using the MTT assay[1]. |
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| References | [1]. Yang ZG, et al. Inhibitory effects of constituents from Morus alba var. multicaulis on differentiation of 3T3-L1 cells and nitric oxide production in RAW264.7 cells. Molecules. 2011 Jul 19;16(7):6010-22. |
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Chemical & Physical Properties
| Molecular Formula | C25H24O6 |
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| Molecular Weight | 420.45400 |
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| Exact Mass | 420.15700 |
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| PSA | 100.13000 |
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| LogP | 5.26970 |
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| Storage condition | 2-8℃ |
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Synonyms
| kuwanon A |
| 5,7,5'-trihydroxy-2',2'-dimethyl-3-(3-methyl-but-2-enyl)-2'H-[2,8']bichromenyl-4-one |
| Kuwanon |
