CAS 125314-13-8|CP21R7
Introduction：Basic information about CAS 125314-13-8|CP21R7, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | CP21R7 | ||
|---|---|---|---|
| CAS Number | 125314-13-8 | Molecular Weight | 317.341 |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 627.4±55.0 °C at 760 mmHg |
| Molecular Formula | C19H15N3O2 | Melting Point | / |
| MSDS | / | Flash Point | 333.2±31.5 °C |
Names
| Name | 3-(3-Aminophenyl)-4-(1-methyl-1H-indol-3-yl)pyrrole-2,5-dione |
|---|---|
| Synonym | More Synonyms |
CP21R7 BiologicalActivity
| Description | CP21R7 is potent GSK-3β inhibitor, with an IC50 of 1.8 nM; CP21R7 also shows inhibitory activitiy against PKCα, with an IC50 of 1900 nM. |
|---|---|
| Related Catalog | Research Areas >>Cancer |
| Target | GSK-3β:1.8 nM (IC50) PKCα:1900 nM (IC50) |
| In Vitro | CP21R7 (Compound 9) is a selective inhibitor of GSK-3β, with an IC50 of 1.8 nM; the IC50 of CP21R7 against PKCα is 1900 nM[1]. CP21R7 (CP21, 3 μM) potently activates canonical Wnt signaling with highest activity. CP21 significantly increases total levels of intracellular β-catenin. CP21 combined with BMP4 induces commitment of hPSCs towards mesoderm[2]. |
| References | [1]. Gong L, et al. Discovery of potent and bioavailable GSK-3beta inhibitors. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1693-6. [2]. Patsch C, et al. Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells. Nat Cell Biol. 2015 Aug;17(8):994-1003. |
Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 627.4±55.0 °C at 760 mmHg |
| Molecular Formula | C19H15N3O2 |
| Molecular Weight | 317.341 |
| Flash Point | 333.2±31.5 °C |
| Exact Mass | 317.116425 |
| LogP | 2.40 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.714 |
| InChIKey | RGTAEYDIDMGJLX-UHFFFAOYSA-N |
| SMILES | Cn1cc(C2=C(c3cccc(N)c3)C(=O)NC2=O)c2ccccc21 |
| Storage condition | -20℃ |
Synonyms
| 3-(3-Aminophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione |
| 1H-Pyrrole-2,5-dione, 3-(3-aminophenyl)-4-(1-methyl-1H-indol-3-yl)- |
| CP21R7 |
| CP21 |
| CP-21R7 |
