CAS 1351635-67-0|ONO-4059 (analog)

Introduction：Basic information about CAS 1351635-67-0|ONO-4059 (analog), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. ONO-4059 (analog) BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	ONO-4059 (analog)
CAS Number	1351635-67-0	Molecular Weight	456.496
Density	1.4±0.1 g/cm3	Boiling Point	714.0±70.0 °C at 760 mmHg
Molecular Formula	C₂₅H₂₄N₆O₃	Melting Point	/
MSDS	/	Flash Point	385.6±35.7 °C

Names

Name	6-Amino-7,9-dihydro-9-[(3S)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-7-(4-phenoxyphenyl)-8H-purin-8-one
Synonym	More Synonyms

ONO-4059 (analog) BiologicalActivity

Description	The product is the analog of ONO-4059, ONO-4059 is a highly potent and selective Btk inhibitor with an IC50 in the sub-nM range. IC50 value: sub-nM range [2]Target: Btkin vitro: ONO-4059 ( analog ) is a selective, once-daily, oral inhibitor of BTK, which has been shown to play a role in the survival and proliferation of malignant B-cells. ONO-4059 (analog) shows a favourable safety profile along with promising efficacy in this difficult-to-treat patient population. [1]in vivo: ONO-4059 (analog) has demonstrated anti-tumour activity in several pre-clinical models.[1] ONO-4059 (analog) potently and dose-dependently reverse clinical arthritis and prevented bone damage in the CIA model.[2]
Related Catalog	Signaling Pathways >>Protein Tyrosine Kinase/RTK >>BtkResearch Areas >>Cancer
References	[1]. Simon Rule,A Phase I Study Of The Oral Btk Inhibitor ONO-4059 In Patients With Relapsed/Refractory B-Cell Lymphoma. November 15, 2013; Blood: 122 (21) [2]. Toshio Yoshizawa, et al. Development of a Bruton's Tyrosine Kinase (Btk) Inhibitor, ONO-4059: Efficacy in a Collagen Induced Arthritis (CIA) Model Indicates Potential Treatment for Rheumatoid Arthritis (RA). Washington, DC November 9-14, 2012. [3]. Yamamoto, et al. Preparation of purinone derivatives as selective Btk inhibitors. From PCT Int. Appl. (2011), WO 2011152351 A1 20111208.

Description

The product is the analog of ONO-4059, ONO-4059 is a highly potent and selective Btk inhibitor with an IC50 in the sub-nM range. IC50 value: sub-nM range [2]Target: Btkin vitro: ONO-4059 ( analog ) is a selective, once-daily, oral inhibitor of BTK, which has been shown to play a role in the survival and proliferation of malignant B-cells. ONO-4059 (analog) shows a favourable safety profile along with promising efficacy in this difficult-to-treat patient population. [1]in vivo: ONO-4059 (analog) has demonstrated anti-tumour activity in several pre-clinical models.[1] ONO-4059 (analog) potently and dose-dependently reverse clinical arthritis and prevented bone damage in the CIA model.[2]

Related Catalog

Signaling Pathways >>Protein Tyrosine Kinase/RTK >>BtkResearch Areas >>Cancer

References

[1]. Simon Rule,A Phase I Study Of The Oral Btk Inhibitor ONO-4059 In Patients With Relapsed/Refractory B-Cell Lymphoma. November 15, 2013; Blood: 122 (21)

[2]. Toshio Yoshizawa, et al. Development of a Bruton's Tyrosine Kinase (Btk) Inhibitor, ONO-4059: Efficacy in a Collagen Induced Arthritis (CIA) Model Indicates Potential Treatment for Rheumatoid Arthritis (RA). Washington, DC November 9-14, 2012.

[3]. Yamamoto, et al. Preparation of purinone derivatives as selective Btk inhibitors. From PCT Int. Appl. (2011), WO 2011152351 A1 20111208.

Chemical & Physical Properties

Density	1.4±0.1 g/cm3
Boiling Point	714.0±70.0 °C at 760 mmHg
Molecular Formula	C₂₅H₂₄N₆O₃
Molecular Weight	456.496
Flash Point	385.6±35.7 °C
Exact Mass	456.190979
LogP	1.82
Vapour Pressure	0.0±2.3 mmHg at 25°C
Index of Refraction	1.677
InChIKey	KSUDUUBCXJUFRL-SFHVURJKSA-N
SMILES	C=CC(=O)N1CCCC(n2c(=O)n(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1
Storage condition	-20℃

Safety Information

Hazard Codes	N

Synonyms

9-[(3S)-1-Acryloyl-3-piperidinyl]-6-amino-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one

8H-Purin-8-one, 6-amino-7,9-dihydro-9-[(3S)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-7-(4-phenoxyphenyl)-

ONO-4059

ONO4059 analog

ONO-4059 (analog)

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