Introduction：Basic information about CAS 957230-65-8|Isofagomine D-Tartrate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Isofagomine D-Tartrate |
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| CAS Number | 957230-65-8 | Molecular Weight | 297.26 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C10H19NO9 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | Afegostat |
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| Synonym | More Synonyms |
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Isofagomine D-Tartrate BiologicalActivity
| Description | Afegostat D-Tartrate is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity[1]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease |
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| Target | GCase[1] |
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| In Vivo | Vivo: Afegostat (AT2101) increases GCase activity in brain, liver, and spleen. Afegostat (100 mg/kg) administrates orally for 4 months to Thy1-aSyn mice improved motor and nonmotor function, abolishes microglial inflammatory response in the substantia nigra, reduces α-synuclein immunoreactivity in nigral dopaminergic neurons, and reduces the number of small α-synuclein aggregates, while increasing the number of large α-synuclein aggregates[1]. |
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| References | [1]. Richter F, et al. A GCase chaperone improves motor function in a mouse model of synucleinopathy. Neurotherapeutics. 2014 Oct;11(4):840-56. |
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Chemical & Physical Properties
| Molecular Formula | C10H19NO9 |
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| Molecular Weight | 297.26 |
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| Exact Mass | 297.105988 |
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| InChIKey | ULBPPCHRAVUQMC-AWUBODBRSA-N |
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| SMILES | O=C(O)C(O)C(O)C(=O)O.OCC1CNCC(O)C1O |
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| Storage condition | 2-8℃ |
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Synonyms
| Isofagomine D-Tartrate |
| Butanedioic acid, 2,3-dihydroxy-, (2S,3S)-, compd. with (3R,4R,5R)-5-(hydroxymethyl)-3,4-piperidinediol (1:1) |
| (2S,3S)-2,3-Dihydroxysuccinic acid - (3R,4R,5R)-5-(hydroxymethyl)-3,4-piperidinediol (1:1) |
| (3R,4R,5R)-5-(Hydroxymethyl)-3,4-piperidinediol (2S,3S)-2,3-Dihydroxybutanedioate |
| Afegostat (D-Tartrate) |
