CAS 1203494-49-8|DASA-58

Introduction：Basic information about CAS 1203494-49-8|DASA-58, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. DASA-58 BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	DASA-58
CAS Number	1203494-49-8	Molecular Weight	453.532
Density	1.5±0.1 g/cm3	Boiling Point	681.5±65.0 °C at 760 mmHg
Molecular Formula	C₁₉H₂₃N₃O₆S₂	Melting Point	/
MSDS	/	Flash Point	366.0±34.3 °C

Names

Name	3-[[4-[(2,3-Dihydro-1,4-benzodioxin-6-yl)sulfonyl]hexahydro-1H-1,4-diazepin-1-yl]sulfonyl]benzenamine
Synonym	More Synonyms

DASA-58 BiologicalActivity

Description	DASA-58 is a potent activator of pyruvate kinase M2 (PKM2) with an AC90 of 680 nM, and an AC50 of 38 nM.
Related Catalog	Signaling Pathways >>Metabolic Enzyme/Protease >>Pyruvate KinaseResearch Areas >>Cancer
References	[1]. Palsson-McDermott EM, et al. Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages. Cell Metab. 2015 Jan 6;21(1):65-80. [2]. Giannoni E, et al. Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs oxphos and prostate cancer metastatic spread. Oncotarget. 2015 Sep 15;6(27):24061-24074.

Description

DASA-58 is a potent activator of pyruvate kinase M2 (PKM2) with an AC90 of 680 nM, and an AC50 of 38 nM.

Related Catalog

Signaling Pathways >>Metabolic Enzyme/Protease >>Pyruvate KinaseResearch Areas >>Cancer

References

[1]. Palsson-McDermott EM, et al. Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages. Cell Metab. 2015 Jan 6;21(1):65-80.

[2]. Giannoni E, et al. Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs oxphos and prostate cancer metastatic spread. Oncotarget. 2015 Sep 15;6(27):24061-24074.

Chemical & Physical Properties

Density	1.5±0.1 g/cm3
Boiling Point	681.5±65.0 °C at 760 mmHg
Molecular Formula	C₁₉H₂₃N₃O₆S₂
Molecular Weight	453.532
Flash Point	366.0±34.3 °C
Exact Mass	453.102814
LogP	2.32
Vapour Pressure	0.0±2.1 mmHg at 25°C
Index of Refraction	1.639
InChIKey	GMHIOMMKSMSRLY-UHFFFAOYSA-N
SMILES	Nc1cccc(S(=O)(=O)N2CCCN(S(=O)(=O)c3ccc4c(c3)OCCO4)CC2)c1
Storage condition	-20℃

Synonyms

Benzenamine, 3-[[4-[(2,3-dihydro-1,4-benzodioxin-6-yl)sulfonyl]hexahydro-1H-1,4-diazepin-1-yl]sulfonyl]-

3-{[4-(2,3-Dihydro-1,4-benzodioxin-6-ylsulfonyl)-1,4-diazepan-1-yl]sulfonyl}aniline

DASA-58

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