Introduction：Basic information about CAS 1449685-96-4|DDR1-IN-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | DDR1-IN-1 |
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| CAS Number | 1449685-96-4 | Molecular Weight | 552.587 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 609.0±55.0 °C at 760 mmHg |
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| Molecular Formula | C30H31F3N4O3 | Melting Point | / |
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| MSDS | / | Flash Point | 322.1±31.5 °C |
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Names
| Name | N-[3-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)oxy]-4-methylphenyl]-4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)benzamide |
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| Synonym | More Synonyms |
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DDR1-IN-1 BiologicalActivity
| Description | DDR1-IN-1 is a potent and selective DDR1 receptor tyrosine kinaseinhibitor with IC50/EC50 of 105 nM/87 nM; 4-fold less potent for DDR2 (IC50= 413 nM).IC50 value: 105 nM [1]Target: DDR1We confirmed the observed binding to DDR1 using an enzymatic kinase assay employing the Lanthascreen technology. In this assay DDR1-IN-1 exhibits an IC50 of 105 nM against DDR1 and 413 nM against DDR2. DDR1-IN-1 and DDR1-IN-2 inhibited basal DDR1 autophosphorylation with an EC50 of 86 nM and 9 nM, respectively. Both DDR1-IN-1 and DDR1-IN-2 demonstrated weaker inhibition of DDR1 autophosphorylation in the absence of collagen stimulation. |
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| Related Catalog | Signaling Pathways >>Protein Tyrosine Kinase/RTK >>Discoidin Domain ReceptorResearch Areas >>Cancer |
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| References | [1]. Kim HG, et al. Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor. ACS Chem Biol. 2013 Oct 18;8(10):2145-50. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 609.0±55.0 °C at 760 mmHg |
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| Molecular Formula | C30H31F3N4O3 |
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| Molecular Weight | 552.587 |
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| Flash Point | 322.1±31.5 °C |
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| Exact Mass | 552.234802 |
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| LogP | 4.70 |
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| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
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| Index of Refraction | 1.602 |
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| InChIKey | AOZPVMOOEJAZGK-UHFFFAOYSA-N |
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| SMILES | CCN1CCN(Cc2ccc(C(=O)Nc3ccc(C)c(Oc4ccc5c(c4)CC(=O)N5)c3)cc2C(F)(F)F)CC1 |
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| Storage condition | -20℃ |
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Synonyms
| 4-[(4-Ethyl-1-piperazinyl)methyl]-N-{4-methyl-3-[(2-oxo-2,3-dihydro-1H-indol-5-yl)oxy]phenyl}-3-(trifluoromethyl)benzamide |
| Benzamide, N-[3-[(2,3-dihydro-2-oxo-1H-indol-5-yl)oxy]-4-methylphenyl]-4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)- |
| DDR1-IN-1 |
