CAS 1353550-13-6|Olmutinib

Introduction：Basic information about CAS 1353550-13-6|Olmutinib, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Olmutinib BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Olmutinib
CAS Number	1353550-13-6	Molecular Weight	486.589
Density	1.3±0.1 g/cm3	Boiling Point	/
Molecular Formula	C₂₆H₂₆N₆O₂S	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	N-[3-[[2-[[4-(4-Methyl-1-piperazinyl)phenyl]amino]thieno[3,2-d]pyrimidin-4-yl]oxy]phenyl]-2-propenamide
Synonym	More Synonyms

Olmutinib BiologicalActivity

Description	Olmutinib (HM61713; BI-1482694) is an irreversible EGFR tyrosine kinase inhibitor that binds to a cysteine residue near the kinase domain.
Related Catalog	Research Areas >>Cancer
Target	EGFRExon 19 deletion:9.2 nM (IC50, Cell Assay) EGFRL858R/T790M:10 nM (IC50, Cell Assay)
In Vitro	Olmutinib potently inhibits EGFR in HCC827 cells expressing EGFRDEL19 (IC50=9.2 nM) and H1975 cells expressing EGFRL858R/T790M (IC50=10 nM). In contrast, the IC50 of olmutinib against cells expressing EGFRWT is 2225 nM[1].
References	[1]. Kim ES, et al. Olmutinib: First Global Approval. Drugs.?2016 Jul;76(11):1153-7.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Molecular Formula	C₂₆H₂₆N₆O₂S
Molecular Weight	486.589
Exact Mass	486.183807
PSA	110.86000
LogP	4.95
Index of Refraction	1.706
InChIKey	FDMQDKQUTRLUBU-UHFFFAOYSA-N
SMILES	C=CC(=O)Nc1cccc(Oc2nc(Nc3ccc(N4CCN(C)CC4)cc3)nc3ccsc23)c1
Storage condition	-20℃

Synonyms

N-{3-[(2-{[4-(4-Methyl-1-piperazinyl)phenyl]amino}thieno[3,2-d]pyrimidin-4-yl)oxy]phenyl}acrylamide

2-Propenamide, N-[3-[[2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]thieno[3,2-d]pyrimidin-4-yl]oxy]phenyl]-

Olmutinib

N-(3-(2-(4-(4-methylpiperazin-1-yl)phenylamino) thieno[3,2-d]pyrimidin-4-yloxy)phenyl)acrylamide

HM71224

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