Introduction：Basic information about CAS 173932-75-7|Gambogenic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Gambogenic acid |
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| CAS Number | 173932-75-7 | Molecular Weight | 630.767 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 818.6±65.0 °C at 760 mmHg |
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| Molecular Formula | C38H46O8 | Melting Point | / |
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| MSDS | / | Flash Point | 253.0±27.8 °C |
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Names
| Name | Gambogenic acid |
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| Synonym | More Synonyms |
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Gambogenic acid BiologicalActivity
| Description | Gambogenic acid is an active ingredient in gamboge, with anticancer activity. Gambogenic acid acts as an effective inhibitor of EZH2, specifically and covalently binds to Cys668 within the EZH2-SET domain, and induces EZH2 ubiquitination[1]. |
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| Related Catalog | Research Areas >>Cancer |
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| Target | EZH2[1] |
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| References | [1]. Wang X, et al. A covalently bound inhibitor triggers EZH2 degradation through CHIP-mediated ubiquitination. EMBO J. 2017 May 2;36(9):1243-1260. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 818.6±65.0 °C at 760 mmHg |
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| Molecular Formula | C38H46O8 |
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| Molecular Weight | 630.767 |
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| Flash Point | 253.0±27.8 °C |
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| Exact Mass | 630.319275 |
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| LogP | 9.42 |
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| Vapour Pressure | 0.0±3.1 mmHg at 25°C |
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| Index of Refraction | 1.619 |
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| InChIKey | RCWNBHCZYXWDOV-VSFMGBBVSA-N |
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| SMILES | CC(C)=CCCC(C)=CCc1c(O)c(CC=C(C)C)c2c(c1O)C(=O)C1=CC3CC4C(C)(C)OC(CC=C(C)C(=O)O)(C3=O)C14O2 |
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| Storage condition | 2-8°C |
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Synonyms
| (2Z)-4-[(1S,2S,13S,15R)-7-[(2E)-3,7-Dimethyl-2,6-octadien-1-yl]-6,8-dihydroxy-17,17-dimethyl-5-(3-methyl-2-buten-1-yl)-10,14-dioxo-3,16-dioxapentacyclo[11.4.1.0.0.0]octadeca-4,6,8,11- tetraen-15-yl]-2-methyl-2-butenoic acid |
| 2-Butenoic acid, 4-[(1R,3aS,5S,12aS)-9-[(2E)-3,7-dimethyl-2,6-octadien-1-yl]-3a,4,5,7-tetrahydro-8,10-dihydroxy-3,3-dimethyl-11-(3-methyl-2-buten-1-yl)-7,13-dioxo-1,5-methano-1H,3H-furo[3,4-d]xanthen-1-yl]-2-methyl-, (2Z)- |
| (2Z)-4-[(1R,3aS,5S,12aS)-9-[(2E)-3,7-Dimethyl-2,6-octadien-1-yl]-3a,4,5,7-tetrahydro-8,10-dihydroxy-3,3-dimethyl-11-(3-methyl-2-buten-1-yl)-7,13-dioxo-1,5-methano-1H,3H-furo[3,4-d]xanthen-1-yl]-2-methyl-2-butenoic acid |
