CAS 20977-05-3|Sodium Aescinate
Introduction：Basic information about CAS 20977-05-3|Sodium Aescinate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Sodium Aescinate | ||
|---|---|---|---|
| CAS Number | 20977-05-3 | Molecular Weight | 1124.2202 |
| Density | / | Boiling Point | / |
| Molecular Formula | C54H83NaO23 | Melting Point | / |
| MSDS | / | Flash Point | / |
Names
| Name | Escin monosodium salt |
|---|---|
| Synonym | More Synonyms |
Sodium Aescinate BiologicalActivity
| Description | Sodium aescinate is a triterpene saponin derived from Aesculus hippocastanum seeds, with anti-inflammatory and antioxidant activities[1]. Sodium aescinate inhibits hepatocellular carcinoma growth by targeting CARMA3/NF-κB pathway[2]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>Others |
| In Vitro | Sodium aescinate can block signals transiting to downstream molecules AKT, ERK, inhibit the proliferation of breast cancer cell MCF-7 cell apoptosis and induced cell apoptosis by suppressing the activation of SRC[3]. |
| In Vivo | Sodium aescinate may effectively controls and improves wound healing in diabetic rats via its anti-inflammatory and antioxidant activities[1]. Sodium aescinate treatment can alleviate the symptom of polycystic ovary syndrome (PCOS) in rat model through regulating the PI3K/Akt/GSK3-β pathway[4]. |
| References | [1]. Zhang Z, et al. The Efficacy of Sodium Aescinate on Cutaneous Wound Healing in Diabetic Rats. Inflammation. 2015 Oct;38(5):1942-8. [2]. Hou H, et al. CARMA3/NF-κB signaling contributes to tumorigenesis of hepatocellular carcinoma and is inhibited by sodium aescinate. World J Gastroenterol. 2019 Sep 28;25(36):5483-5493. [3]. Qi SM, et al. Effect of sodium aescinate in inducing human breast cancer MCF-7 cells apoptosis by inhibiting AKT, ERK and upstream signal SRC activity. Zhongguo Zhong Yao Za Zhi. 2015 Aug;40(16):3267-72. [4]. Chen L, et al. Effect of sodium aescinate treatment on PCOS rat model with insulin resistance. Bratisl Lek Listy. 2017;118(4):223-227. |
Chemical & Physical Properties
| Molecular Formula | C54H83NaO23 |
|---|---|
| Molecular Weight | 1124.2202 |
| InChIKey | OJTQULAMLNBGOY-NREQLCGPSA-N |
| SMILES | CC(=O)OC(C)C(C)C(=O)OCC12C3CC4(C)C(=CCC5C6(C)CCC(OC7OC(C(=O)O)C(OC8OC(CO)C(O)C(O)C8O)C(O)C7OC7OCC(O)C(O)C7O)C(C)(CO)C6CCC54C)C1CC(C)(C)C(O3)C2O.[Na+] |
Synonyms
| 3-methyl-pyridine-2-carbonitrile |
| 3-methyl-2-pyridinecarbonitrile |
| 2-cyano-3-methly pyridine |
| 2-cyano-b-picoline |
| 3-methylpyridine-2-carbonitrile |
| 2-Cyano-3-methylpyridine |
| (h4tes4)[qr] |
| akrochem tdec |
| diethyl-carbamodithioicacitetrakis(anhydrosulfide)withthiotelluricac |
| Sodium escinate |
