Introduction：Basic information about CAS 133876-92-3|Nattokinase, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Nattokinase |
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| CAS Number | 133876-92-3 | Molecular Weight | 517.122 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C20H23BCl2N2O9 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | Nattokinase |
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| Synonym | More Synonyms |
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Nattokinase BiologicalActivity
| Description | Nattokinase is a potent fibrinolytic enzyme. Nattokinase can break down blood clots by directly hydrolyzing fibrin and plasmin substrate. Nattokinase can be used for the research of cardiovascular diseases[1]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Others >>Others |
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| In Vitro | Nattokinase dissolves 94% blood clot at ten minutes and degrades the fibrin clot after two hours of incubation[2]. |
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| In Vivo | Nattokinase (150-250 mg/kg; oral gavage twice daily for 2 days) exhibits fibrinolytic activity and dissolves blood clots in vivo[3]. Animal Model: Sprague-Dawley (SD) rats (180-220 g) are injected κ-Carrageenan[3] Dosage: 150, 250 mg/kg Administration: Oral gavage twice daily for 2 days Result: Increased the plasma concentration of fibrin/fibrinogen degradation products (FDPs) and D-Dimer in a dose-dependent manner. Decreased the fraction of the vessel cross section occupied by thrombosis. |
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| References | [1]. Weng Y, et, al. Nattokinase: An Oral Antithrombotic Agent for the Prevention of Cardiovascular Disease. Int J Mol Sci. 2017 Feb 28; 18(3):523. [2]. Chandrasekaran SD, et, al. Exploring the In Vitro Thrombolytic Activity of Nattokinase From a New Strain Pseudomonas aeruginosa CMSS. Jundishapur J Microbiol. 2015 Oct 26; 8(10): e23567. [3]. Xu J, et, al. Thrombolytic effects in vivo of nattokinase in a carrageenan-induced rat model of thrombosis. Acta Haematol. 2014; 132(2): 247-53. |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Molecular Formula | C20H23BCl2N2O9 |
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| Molecular Weight | 517.122 |
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| Exact Mass | 516.087341 |
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| Index of Refraction | 1.580 |
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Synonyms
| 4-(Carboxymethyl)-2-[(1R)-1-{[N-(2,5-dichlorobenzoyl)glycyl]amino}-3-methylbutyl]-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid |
| 1,3,2-Dioxaborinane-4-acetic acid, 4-carboxy-2-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-6-oxo- |
| Nattoesse Haruno-Ogawa |
