Introduction：Basic information about CAS 60398-08-5|Ac-(6-O-stearoyl)-muramyl-Ala-D-Glu-NH2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Ac-(6-O-stearoyl)-muramyl-Ala-D-Glu-NH2 |
|---|
| CAS Number | 60398-08-5 | Molecular Weight | 758.940 |
|---|
| Density | 1.2±0.1 g/cm3 | Boiling Point | 1018.5±65.0 °C at 760 mmHg |
|---|
| Molecular Formula | C37H66N4O12 | Melting Point | / |
|---|
| MSDS | / | Flash Point | 569.8±34.3 °C |
|---|
Names
| Name | N-Acetylmuramyl-L-Alanyl-D-Isoglutamine-6-O-Stearoyl |
|---|
| Synonym | More Synonyms |
|---|
Ac-(6-O-stearoyl)-muramyl-Ala-D-Glu-NH2 BiologicalActivity
| Description | L18-MDP is a derivative of muramyl dipeptide, an antibacterial agent. L18-MDP has antibacterial activity and has potential applications in bacterial and fungal infections[1]. |
|---|
| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>FungalSignaling Pathways >>Anti-infection >>Bacterial |
|---|
| In Vivo | L18-MDP (100 µg；皮下注射；单剂量) 在感染大肠杆菌或克雷白氏肺炎杆菌的小鼠中具有抗感染作用[1]。 L18-MDP (100 µg 或 1000 µg；皮下注射、腹腔注射、静脉注射或口服；单剂量) 提高了感染大肠杆菌小鼠的存活率，改善了感染李斯特菌的小鼠病理组织[1]。 L18-MDP (100 µg 或 200 µg 皮下注射或腹腔注射；一天一次持续 3 天) 提高了感染白色念珠菌小鼠的存活率[1]。 Animal Model: Mice infected with Escherichia coli, Klebsiella pneumoniae or Listeria monocytogenes[1]. Dosage: 100 µg or 1000 µg. Administration: Subcutaneous injection, intraperitoneal injection, intravenous injection or oral gavage; single dose. Result: Strengthened the phagocytosis of the microorganisms, weakened the virus activity, increased the survival rate and improved the pathological tissue. Animal Model: Mice infected with Candida albicans[1]. Dosage: 100 µg or 200 µg. Administration: Subcutaneous injection or intraperitoneal injection; once daily for 3 days. Result: Strengthened the phagocytosis of the microorganisms, weakened the virus activity, increased the survival rate and improved the pathological tissue. |
|---|
| References | [1]. Osada Y, et al. Effect of L18-MDP(Ala), a synthetic derivative of muramyl dipeptide, on nonspecific resistance of mice to microbial infections. Infect Immun. 1982 Jul;37(1):292-300. |
|---|
Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
|---|
| Boiling Point | 1018.5±65.0 °C at 760 mmHg |
|---|
| Molecular Formula | C37H66N4O12 |
|---|
| Molecular Weight | 758.940 |
|---|
| Flash Point | 569.8±34.3 °C |
|---|
| Exact Mass | 758.467712 |
|---|
| LogP | 6.48 |
|---|
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
|---|
| Index of Refraction | 1.532 |
|---|
Synonyms
| (2R)-2-{[(2S)-2-{[2-({(2S,3R,4R,5S,6R)-3-Acetamido-2,5-dihydroxy-6-[(stearoyloxy)methyl]tetrahydro-2H-pyran-4-yl}oxy)propanoyl]amino}propanoyl]amino}-5-amino-5-oxopentanoic acid |
| Ac-(6-O-stearoyl)-muramyl-Ala-D-Glu-NH2 |
