Introduction：Basic information about CAS 9001-00-7|Bromelain, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Bromelain |
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| CAS Number | 9001-00-7 | Molecular Weight | 226.232 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 656.2±55.0 °C at 760 mmHg |
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| Molecular Formula | C9H14N4O3 | Melting Point | / |
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| MSDS | / | Flash Point | 350.7±31.5 °C |
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Names
| Name | Bromelain |
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| Synonym | More Synonyms |
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Bromelain BiologicalActivity
| Description | Bromelain is an anti-inflammatory drug derived from pineapple stem that acts through down-regulation of plasma kininogen, inhibition of Prostaglandin E2 expression, degradation of advanced glycation end product receptors and regulation of angiogenic biomarkers as well as antioxidant action upstream in the COX-pathway[1]. Bromelain exhibits various fibrinolytic, antiedematous, antithrombotic, and anti-inflammatory activities. Bromelain also possesses some anticancerous activities and promotes apoptotic cell death[2]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Cancer |
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| In Vivo | Bromelain (40 mg/kg; intraperitoneal injection; daily; for 7 days; male Sprague-Dawley rats) pretreatment reduces the motor dysfunction in the parkinsonian rat model of parkinson's disease (PD). 6-OHDA injection resulted in marked motor impairment which is prevented by pretreatment with Bromelain prior to the lesion[1]. Animal Model: Male Sprague-Dawley rats injected with 6-OHDA[1] Dosage: 40 mg/kg Administration: Intraperitoneal injection; daily; for 7 days Result: Reduced the motor dysfunction in the parkinsonian rat model of parkinson's disease (PD). |
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| References | [1]. Adu TS, et al. Effects of bromelain on motor responses following intra-medial forebrain bundle 6-OHDA injection in rat model of parkinsonism. Metab Brain Dis. 2019 Jul 22. [2]. Pavan R, et al. Properties and therapeutic application of bromelain: a review. Biotechnol Res Int. 2012;2012:976203. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 656.2±55.0 °C at 760 mmHg |
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| Molecular Formula | C9H14N4O3 |
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| Molecular Weight | 226.232 |
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| Flash Point | 350.7±31.5 °C |
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| Exact Mass | 226.106583 |
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| LogP | -2.17 |
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| Appearance of Characters | powder | yellow-brown |
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| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
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| Index of Refraction | 1.591 |
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| Storage condition | −20°C |
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| Water Solubility | soluble |
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Safety Information
| Hazard Codes | B,Xn |
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| Risk Phrases | 36/37/38-42 |
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| Safety Phrases | 22-24-26-36/37 |
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| WGK Germany | 3 |
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| HS Code | 35079090 |
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Synonyms
| 2-[(3-Aminopropanoyl)amino]-3-(1H-imidazol-4-yl)propanoic acid |
| Histidine, β-alanyl- |
| b-Alanylhistidine |
| β-Alanylhistidine |
| carnosine |
| N-(3-Aminopropanoyl)histidine |
| EINECS 253-387-5 |
