Introduction：Basic information about CAS 1009734-33-1|HZ-1157, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | HZ-1157 |
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| CAS Number | 1009734-33-1 | Molecular Weight | 232.282 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 471.6±53.0 °C at 760 mmHg |
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| Molecular Formula | C12H16N4O | Melting Point | / |
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| MSDS | / | Flash Point | 239.0±30.9 °C |
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Names
| Name | 5-(tert-butoxy)quinazoline-2,4-diamine |
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| Synonym | More Synonyms |
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HZ-1157 BiologicalActivity
| Description | HZ-1157 inhibits HCV NS3/4A protease with an IC50 of 1.0 μmol/L. HZ-1157 (4a) has a high dengue virus inhibitory activity (EC50 = 0.15 μM) and is a relatively nontoxic (CC50 > 10 μM) dengue antiviral agent[1][2]. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Metabolic Enzyme/Protease >>HCV ProteaseResearch Areas >>Inflammation/Immunology |
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| Target | IC50: 1.0 μmol/L (HCV NS3/4A protease)[2]. |
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| In Vitro | HZ-1157 (4a) is known to possess a broad spectrum of biological activities, such as protein lysine methyltransferase G9a inhibition, SMN2 promoter activation, dihydrofolate reductase inhibition, and others[1][2]. Cell Viability Assay[2]. Cell Line: HZ-1157 (4a) is known to possess a broad spectrum of biological activities, such as protein lysine methyltransferase G9a inhibition, SMN2 promoter activation, dihydrofolate reductase inhibition, and others. Concentration: 0-10 μmol/L. Incubation Time: 72 h. Result: Inhibited HCV infection in vitro with an IC50 of 0.82 μmol/L. |
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| References | [1]. Ye Yu, et al. Discovering Novel anti-HCV Compounds With Inhibitory Activities Toward HCV NS3/4A Protease. Acta Pharmacol Sin. 2014 Aug;35(8):1074-81. [2]. Bo Chao, et al. Discovery and Optimization of 2,4-diaminoquinazoline Derivatives as a New Class of Potent Dengue Virus Inhibitors. J Med Chem . 2012 Apr 12;55(7):3135-43. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 471.6±53.0 °C at 760 mmHg |
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| Molecular Formula | C12H16N4O |
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| Molecular Weight | 232.282 |
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| Flash Point | 239.0±30.9 °C |
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| Exact Mass | 232.132416 |
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| PSA | 87.05000 |
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| LogP | 2.10 |
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| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
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| Index of Refraction | 1.658 |
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| InChIKey | JQHKDYFLRJIBLX-UHFFFAOYSA-N |
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| SMILES | CC(C)(C)Oc1cccc2nc(N)nc(N)c12 |
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| Storage condition | -20℃ |
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Synonyms
| 2,4-Quinazolinediamine, 5-(1,1-dimethylethoxy)- |
| 5-tert-butoxy-2,4-diaminoquinazoline |
| 5-tert-butoxyquinazoline-2,4-diamine |
| HZ-1157 |
| 5-[(2-Methyl-2-propanyl)oxy]-2,4-quinazolinediamine |
