CAS 81203-57-8|(S)-Falcarinol
Introduction：Basic information about CAS 81203-57-8|(S)-Falcarinol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (S)-Falcarinol | ||
|---|---|---|---|
| CAS Number | 81203-57-8 | Molecular Weight | 244.37200 |
| Density | / | Boiling Point | / |
| Molecular Formula | C17H24O | Melting Point | / |
| MSDS | / | Flash Point | / |
Names
| Name | (S,Z)-heptadeca-1,9-dien-4,6-diyne-3-ol |
|---|---|
| Synonym | More Synonyms |
(S)-Falcarinol BiologicalActivity
| Description | (S)-Falcarinol (Panaxynol), one of the major polyacetylenes isolated from Panax ginseng, has antitumor activity. (S)-Falcarinol (Panaxynol) is the most potent antiplatelet agent in ginseng and its mechanism of action is chiefly due to the inhibition of thromboxane formation. (S)-Falcarinol (Panaxynol) is a potent Nrf2 activator[1][2][3]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>NF-κB >>Keap1-Nrf2Research Areas >>Cardiovascular Disease |
| Target | Nrf2[3] |
| References | [1]. Mayer SF, et al. Chemoenzymatic asymmetric total syntheses of antitumor agents (3R,9R,10R)- and (3S,9R,10R)-Panaxytriol and (R)- and (S)-Falcarinol from Panax ginseng using an enantioconvergent enzyme-triggered cascade reaction. J Org Chem. 2002 Dec 27;67(26):9115-21. [2]. Teng CM,et al. Antiplatelet actions of panaxynol and ginsenosides isolated from ginseng. Biochim Biophys Acta. 1989 Mar 24;990(3):315-20. [3]. Qu C, et al. Identifying panaxynol, a natural activator of nuclear factor erythroid-2 related factor 2 (Nrf2) from American ginseng as a suppressor of inflamed macrophage-induced cardiomyocyte hypertrophy. J Ethnopharmacol. 2015 Jun 20;168:326-36. |
Chemical & Physical Properties
| Molecular Formula | C17H24O |
|---|---|
| Molecular Weight | 244.37200 |
| Exact Mass | 244.18300 |
| PSA | 20.23000 |
| LogP | 3.84690 |
| InChIKey | UGJAEDFOKNAMQD-MQNTZWLQSA-N |
| SMILES | C=CC(O)C#CC#CCC=CCCCCCCC |
Synonyms
| (S)-Panaxynol |
| (3S)-falcarinol |
| (S)-Falcarinol |
| (+)-falcarinol |
| S-falcarinol |
| 3S-falcarinol |
| (Z)-(S)-Heptadeca-1,9-diene-4,6-diyn-3-ol |
