CAS 101219-61-8|Picrasidine Q

Introduction：Basic information about CAS 101219-61-8|Picrasidine Q, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NamePicrasidine Q
CAS Number101219-61-8Molecular Weight266.25200
Density/Boiling Point/
Molecular FormulaC15H10N2O3Melting Point/
MSDS/Flash Point/

Names

Name4-hydroxy-5-methoxy-canthin-6-one
SynonymMore Synonyms

Picrasidine Q BiologicalActivity

DescriptionPicrasidine Q, an alkaloid component extracted from Angelica keiskei species, has the capacity of anti-cell transformation and anti-cancer. Picrasidine Q induces cell apoptosis and G1 phase arrest in human esophageal cancer cell lines, and directly inhibits FGFR2 kinase activity[1].
Related CatalogSignaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>Protein Tyrosine Kinase/RTK >>FGFR
Target

FGFR2

In VitroPicrasidine Q (0~60 μM; 3 hours; ESCC cells) suppresses downstream signaling of FGFR2 in ESCC cells[1]. Picrasidine Q (0~60 μM; 48 and 72 hours; ESCC cells) induces cell cycle arrest and apoptosis[1]. Picrasidine Q (0~60 μM; 24~72 hours; ESCC cells) suppresses the growth of ESCC cells[1]. Picrasidine Q (0~60 μM; 30 minutes; JB6Cl41 cells) inhibits proliferation by inhibition of G1/S cell cycle transition[1]. Picrasidine Q (12.5, 25 or 50 μM) can inhibit the FGFR2 kinase activity in a dose-dependent manner[1]. Western Blot Analysis[1] Cell Line: ESCC cells Concentration: 0~60 μM Incubation Time: 3 hours Result: Suppressed downstream signaling of FGFR2 in ESCC cells. Apoptosis Analysis[1] Cell Line: ESCC cells Concentration: 0~60 μM Incubation Time: 48 and 72 hours Result: Induced cell cycle arrest and apoptosis. Cell Cytotoxicity Assay[1] Cell Line: ESCC cells Concentration: 0~60 μM Incubation Time: 24~72 hours Result: Suppressed the growth of ESCC cells. Cell Cycle Analysis[1] Cell Line: JB6Cl41 cells Concentration: 0~60 μM Incubation Time: 30 minutes Result: Inhibited proliferation by inhibition of G1/S cell cycle transition.
References

[1]. Shi Y, et al. FGFR2 regulation by picrasidine Q inhibits the cell growth and induces apoptosis in esophageal squamous cell carcinoma. J Cell Biochem. 2018;119(2):2231-2239.

Chemical & Physical Properties

Molecular FormulaC15H10N2O3
Molecular Weight266.25200
Exact Mass266.06900
PSA63.83000
LogP2.15290

Synonyms

5-methoxy-4-hydroxycanthin-6-one
picrasidine Q
4-Hydroxy-5-methoxy-indolo[3,2,1-de][1,5]naphthyridin-6-one
4-hydroxy-5-methoxycanthin-6-one
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