CAS 22550-15-8|Isocryptotanshinone

Introduction：Basic information about CAS 22550-15-8|Isocryptotanshinone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Isocryptotanshinone BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Isocryptotanshinone
CAS Number	22550-15-8	Molecular Weight	296.36000
Density	/	Boiling Point	/
Molecular Formula	C₁₉H₂₀O₃	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	Isocryptotanshinon
Synonym	More Synonyms

Isocryptotanshinone BiologicalActivity

Description	Isocryptotanshinone is a potent signal transducer and activator of transcription 3 (STAT3) and protein tyrosine phosphatase 1B PTP1B inhibitor, with an IC50 of 56.1 μM for PTP1B.
Related Catalog	Signaling Pathways >>Metabolic Enzyme/Protease >>PhosphataseSignaling Pathways >>JAK/STAT Signaling >>STATSignaling Pathways >>Stem Cell/Wnt >>STATResearch Areas >>Cancer
Target	STAT3 PTP1B:56.1 μM (IC50)
In Vitro	It is showed that tanshinones significantly inhibited A549 proliferation and Isocryptotanshinone (ICTS) exhibits the strongest activity. Isocryptotanshinone inhibits the constitutive STAT3 and p-STAT3 (Y705) expression in concentration and time-dependent manners. Isocryptotanshinone dramatically inhibits the IL-6-stimulated expression of p-STAT3 (Y705) in a time-dependent manner[1].
References	[1]. Guo S, et al. Isocryptotanshinone, a STAT3 inhibitor, induces apoptosis and pro-death autophagy in A549 lung cancer cells. J Drug Target. 2016 Dec;24(10):934-942. [2]. Han YM, et al. PTP1B inhibitory effect of abietane diterpenes isolated from Salvia miltiorrhiza. Biol Pharm Bull. 2005 Sep;28(9):1795-7.

Chemical & Physical Properties

Molecular Formula	C₁₉H₂₀O₃
Molecular Weight	296.36000
Exact Mass	296.14100
PSA	43.37000
LogP	3.59990
InChIKey	VUIHARLRBGHPEA-UHFFFAOYSA-N
SMILES	CC1COC2=C1C(=O)c1ccc3c(c1C2=O)CCCC3(C)C

Safety Information

Hazard Codes	Xi

Synonyms

4,4,8-Trimethyl-2,3,8,9-tetrahydro-1H,4H-10-oxa-cyclopenta[b]phenanthrene-7,11-dione

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