Introduction：Basic information about CAS 1206163-45-2|Solcitinib, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Solcitinib |
|---|
| CAS Number | 1206163-45-2 | Molecular Weight | 389.45000 |
|---|
| Density | 1.4±0.1 g/cm3 | Boiling Point | / |
|---|
| Molecular Formula | C22H23N5O2 | Melting Point | / |
|---|
| MSDS | / | Flash Point | / |
|---|
Names
| Name | Solcitinib |
|---|
| Synonym | More Synonyms |
|---|
Solcitinib BiologicalActivity
| Description | Solcitinib is an orally active, competitive, potent, selective JAK1 inhibitor, with an IC50 of 9.8 nM, and 11-, 55- and 23-fold selectivity over JAK2, JAK3 and TYK2, respectively; Solcitinib is used in the research of moderate-to-severe plaque-type psoriasis. |
|---|
| Related Catalog | Research Areas >>Inflammation/Immunology |
|---|
| Target | JAK1:9.8 nM (IC50) |
|---|
| In Vitro | Solcitinib is an orally active, competitive, potent, selective JAK1 inhibitor, with an IC50 of 9.8 nM, and 11-, 55- and 23-fold selectivity over JAK2, JAK3 and TYK2, respectively. Solcitinib is used in the research of moderate-to-severe plaque-type psoriasis[1]. |
|---|
| References | [1]. Ludbrook VJ, et al. Investigation of selective JAK1 inhibitor GSK2586184 for the treatment of psoriasis in a randomized placebo-controlled phase IIa study. Br J Dermatol. 2016 May;174(5):985-95. |
|---|
Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
|---|
| Molecular Formula | C22H23N5O2 |
|---|
| Molecular Weight | 389.45000 |
|---|
| Exact Mass | 389.18500 |
|---|
| PSA | 79.60000 |
|---|
| LogP | 1.51 |
|---|
| Index of Refraction | 1.723 |
|---|
| InChIKey | MPYACSQFXVMWNO-UHFFFAOYSA-N |
|---|
| SMILES | CC1(C)CN(C(=O)c2ccc(-c3cccc4nc(NC(=O)C5CC5)nn34)cc2)C1 |
|---|
| Storage condition | 2-8℃ |
|---|
Synonyms
| N-(5-{4-[(3,3-Dimethyl-1-azetidinyl)carbonyl]phenyl}[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide |
| UNII-3V7GQ1260K |
| N-(5-{4-[(3,3-dimethylazetidin-1-yl)carbonyl]phenyl}[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide |
| G154578 |
| solcitinibum |
| GSK2586184A |
| GLPG0778 |
| Cyclopropanecarboxamide, N-[5-[4-[(3,3-dimethyl-1-azetidinyl)carbonyl]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]- |
| solcitinib |
