Introduction：Basic information about CAS 24268-41-5|Furanodienone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Furanodienone |
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| CAS Number | 24268-41-5 | Molecular Weight | 230.302 |
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| Density | 1.0±0.1 g/cm3 | Boiling Point | 363.8±42.0 °C at 760 mmHg |
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| Molecular Formula | C15H18O2 | Melting Point | / |
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| MSDS | / | Flash Point | 172.0±20.6 °C |
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Names
| Name | furanodienone |
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| Synonym | More Synonyms |
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Furanodienone BiologicalActivity
| Description | Furanodienone is one of the major bioactive constituents derived from Rhizoma Curcumae. Furanodienone induced apoptosis[1]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Cancer |
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| In Vitro | Furanodienone (0-573.8 μM; 24 hours) exhibits IC50 values : 56.4 μM (RKO), 73.7 μM (sw480), 251.1 μM (HT-29), 412.5 μM (sw620) and 573.8 μM (LoVo) at 24 hours, while that in 48 h are 51.8 μM (RKO), 44.18 μM (sw480), 168.9 μM (HT-29), 314.2 μM (sw620) and 502.1 μM (LoVo), respectively[1]. Furanodienone (0-150 μM; 24 hours) induces apoptosis and shows increase in caspase-9 and -3 activity has been observed in both cells, whereas a relative minor effect on that of caspase-8 in RKO and HT-29 cells[1]. Furanodienone (0-150 μM; 24 hours) increases the apoptotic rates from 2.34±0.45% to 19.45±2.37% and 27.34±0.79%, in RKO cells at 75 and 150 μM. whereas 12.4±1.08 and 20.64±3.02% apoptosis at the concentration of 75 and 150 μM are observed in HT-29 cells compared with 2.89±0.26%[1]. Western Blot Analysis[1] Cell Line: RKO and HT-29 cells Concentration: 0 μM; 50 μM; 100 μM; 150 μM Incubation Time: 24 hours Result: Increased caspase-9 and -3. Apoptosis Analysis[1] Cell Line: RKO and HT-29 cells Concentration: 0 μM; 75 μM; 150 μM Incubation Time: 24 hours Result: Induced apoptosis of colorectal cells (RKO and HT-29). |
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| References | [1]. Li YW, et al. Furanodienone induces cell cycle arrest and apoptosis by suppressing EGFR/HER2 signaling in HER2-overexpressing human breast cancer cells. Cancer Chemother Pharmacol. 2011 Nov;68(5):1315-23. |
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Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
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| Boiling Point | 363.8±42.0 °C at 760 mmHg |
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| Molecular Formula | C15H18O2 |
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| Molecular Weight | 230.302 |
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| Flash Point | 172.0±20.6 °C |
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| Exact Mass | 230.130676 |
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| PSA | 30.21000 |
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| LogP | 4.76 |
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| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
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| Index of Refraction | 1.510 |
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| InChIKey | XVOHELPNOXGRBQ-NXAIOARDSA-N |
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| SMILES | CC1=CC(=O)c2c(C)coc2CC(C)=CCC1 |
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| Storage condition | 2-8℃ |
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Synonyms
| Furanodienon |
| Cyclodeca[b]furan-4(7H)-one, 8,11-dihydro-3,6,10-trimethyl-, (5Z)- |
| furanodien-6-one |
| (5Z)-3,6,10-Trimethyl-8,11-dihydrocyclodeca[b]furan-4(7H)-one |
| furanodiene-6-one |
| (1(10)E,4E)-8,12-epoxygermacra-1(10),4,7,11-tetraen-6-one |
| (5E,9E)-3,6,10-Trimethyl-8,11-dihydro-7H-cyclodeca[b]furan-4-one |
