CAS 19942-02-0|Gymnestrogenin
Introduction：Basic information about CAS 19942-02-0|Gymnestrogenin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Gymnestrogenin | ||
|---|---|---|---|
| CAS Number | 19942-02-0 | Molecular Weight | 490.71500 |
| Density | / | Boiling Point | / |
| Molecular Formula | C30H50O5 | Melting Point | 288-289 °C |
| MSDS | / | Flash Point | / |
Names
| Name | (3β,16β,21β)-olean-12-ene-3,16,21,23,28-pentol |
|---|---|
| Synonym | More Synonyms |
Gymnestrogenin BiologicalActivity
| Description | Gymnestrogenin is a pentahydroxytriterpene from the leaves of Gymnema sylvestre R.Br[1]. Gymnestrogenin is a LXR antagonist with IC50s of 2.5 and 1.4 μM for LXRα and LXRβ transactivation, respectively. Gymnestrogenin reduces the transcriptional activity of LXR even on its own promoter, thus reducing the mRNA expression[2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>LXRResearch Areas >>Metabolic Disease |
| Target | IC50: 2.5 μM (LXRα) and 1.4 μM (LXRβ)[2] |
| In Vitro | Gymnestrogenin, reducing the expression of SREBP1c and ABCA1 in vitro, is able to decrease lipid accumulation in HepG2 cells[2]. |
| References | [1]. Stöcklin W, et al. [Gymnestrogenin, a new pentahydroxytriterpene from the leaves of Gymnema sylvestre R.Br]. Helv Chim Acta. 1968;51(6):1235-42. [2]. Renga B, et al. Molecular decodification of gymnemic acids from Gymnema sylvestre. Discovery of a new class of liver X receptor antagonists. Steroids. 2015 Apr;96:121-31. |
Chemical & Physical Properties
| Melting Point | 288-289 °C |
|---|---|
| Molecular Formula | C30H50O5 |
| Molecular Weight | 490.71500 |
| Exact Mass | 490.36600 |
| PSA | 101.15000 |
| LogP | 4.05530 |
| InChIKey | SIBYGGBNBRCVQI-JGBRNIEFSA-N |
| SMILES | CC1(C)CC2C3=CCC4C5(C)CCC(O)C(C)(CO)C5CCC4(C)C3(C)CC(O)C2(CO)CC1O |
Synonyms
| Gymnestrogenin |
| (3S,4aS,5S,6aS,6bR,8aR,9R,10S,12aR,12bR,14bS)-4a,9-Bis-hydroxymethyl-2,2,6a,6b,9,12a-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydro-picene-3,5,10-triol |
| gymnestrogenin |
| 3β,16β,21β,23,28-pentahydroxyolean-12-ene |
