Introduction：Basic information about CAS 34981-25-4|Kuraridine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Kuraridine |
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| CAS Number | 34981-25-4 | Molecular Weight | 438.51300 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C26H30O6 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | Kuraridine |
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| Synonym | More Synonyms |
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Kuraridine BiologicalActivity
| Description | Kuraridine is a prenylated flavonol extract from the roots of Sophora flavescens. Kuraridine an inhibitory effect on cGMP specific phosphodiesterase type 5 (PDE5) and has an IC50 of 0.64 μM[1]. |
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| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>Phosphodiesterase (PDE)Research Areas >>Others |
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| Target | PDE5:0.64 μM (IC50) |
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| In Vitro | Kuraridine shows potent inhibitory activity (IC50=0.64 μM) against cGMP PDE5 with 2.0- and 12.9-fold selectivity over PDE3 and PDE4, respectively[1]. Kuraridine induces pronounced chloride inward currents in the absence of GABA. Thecurrents does not exceed 10% of the maximal IGABA induced by a saturating GABA concentration (1 mM)[2]. Kuraridine induces a concentration–response curves for IGABA enhancement (EC50=4.0±2.4 μM) in Xenopus oocytes expressing GABAA receptors composed of α1, β2, and γ2S subunits[2]. |
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| References | [1]. Hye Joo Shin, et al. A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5. Bioorg Med Chem Lett. 2002 Sep 2;12(17):2313-6. [2]. Xinzhou Yang, et al. HPLC-based activity profiling for GABAA receptor modulators from the traditional Chinese herbal drug Kushen (Sophora flavescens root). Mol Divers. 2011 May;15(2):361-72. |
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Chemical & Physical Properties
| Molecular Formula | C26H30O6 |
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| Molecular Weight | 438.51300 |
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| Exact Mass | 438.20400 |
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| PSA | 107.22000 |
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| LogP | 5.50480 |
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| InChIKey | PIAPWPAWQGDOMN-PKNBQFBNSA-N |
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| SMILES | C=C(C)C(CC=C(C)C)Cc1c(O)cc(OC)c(C(=O)C=Cc2ccc(O)cc2O)c1O |
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Synonyms
| 6'-methoxy-2,4,2',4'-tetrahydroxy-3'-lavandulylchalcone |
| kuraridin |
| kuraridine |
| (E)-1-[2,4-Dihydroxy-3-(2-isopropenyl-5-methyl-hex-4-enyl)-6-methoxy-phenyl]-3-(2,4-dihydroxy-phenyl)-propenone |
