Introduction：Basic information about CAS 945553-91-3|(R,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (R,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide |
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| CAS Number | 945553-91-3 | Molecular Weight | 485.938 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 676.9±55.0 °C at 760 mmHg |
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| Molecular Formula | C24H25ClFN5O3 | Melting Point | / |
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| MSDS | / | Flash Point | 363.2±31.5 °C |
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Names
| Name | (2E)-N-{4-[(3-Chloro-4-fluorophenyl)amino]-7-[(3R)-tetrahydro-3-furanyloxy]-6-quinazolinyl}-4-(dimethylamino)-2-butenamide |
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| Synonym | More Synonyms |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 676.9±55.0 °C at 760 mmHg |
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| Molecular Formula | C24H25ClFN5O3 |
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| Molecular Weight | 485.938 |
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| Flash Point | 363.2±31.5 °C |
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| Exact Mass | 485.162994 |
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| LogP | 3.59 |
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| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
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| Index of Refraction | 1.668 |
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| InChIKey | ULXXDDBFHOBEHA-QDLOVBKTSA-N |
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| SMILES | CN(C)CC=CC(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1OC1CCOC1 |
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| Water Solubility | Insuluble (7.3E-5 g/L) (25 ºC) |
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Synonyms
| 2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3R)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-, (2E)- |
| (2E)-N-{4-[(3-Chloro-4-fluorophenyl)amino]-7-[(3R)-tetrahydro-3-furanyloxy]-6-quinazolinyl}-4-(dimethylamino)-2-butenamide |
| (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3R)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide |
| Afatinib Impurity 3 |
