Introduction：Basic information about CAS 761373-05-1|2R,4S-Sacubitril, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 2R,4S-Sacubitril |
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| CAS Number | 761373-05-1 | Molecular Weight | 411.491 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 656.9±55.0 °C at 760 mmHg |
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| Molecular Formula | C24H29NO5 | Melting Point | / |
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| MSDS | / | Flash Point | 351.1±31.5 °C |
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Names
| Name | 4-{[(2R,4S)-1-(4-Biphenylyl)-5-ethoxy-4-methyl-5-oxo-2-pentanyl]amino}-4-oxobutanoic acid |
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| Synonym | More Synonyms |
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2R,4S-Sacubitril BiologicalActivity
| Description | 2R,4S-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and Drug Administration for use in combination with valsartan for the treatment of patients with heart failure. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Cardiovascular Disease |
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| References | [1]. Shi J, et al. Sacubitril Is Selectively Activated by Carboxylesterase 1 (CES1) in the Liver and the Activation Is Affected by CES1 Genetic Variation. Drug Metab Dispos. 2016 Apr;44(4):554-9. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 656.9±55.0 °C at 760 mmHg |
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| Molecular Formula | C24H29NO5 |
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| Molecular Weight | 411.491 |
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| Flash Point | 351.1±31.5 °C |
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| Exact Mass | 411.204559 |
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| LogP | 3.96 |
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| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
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| Index of Refraction | 1.549 |
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| InChIKey | PYNXFZCZUAOOQC-LAUBAEHRSA-N |
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| SMILES | CCOC(=O)C(C)CC(Cc1ccc(-c2ccccc2)cc1)NC(=O)CCC(=O)O |
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| Storage condition | 2-8℃ |
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Synonyms
| 4-{[(2R,4S)-1-(4-Biphenylyl)-5-ethoxy-4-methyl-5-oxo-2-pentanyl]amino}-4-oxobutanoic acid |
| [1,1'-Biphenyl]-4-pentanoic acid, γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-, α-ethyl ester, (αS,γR)- |
| 4-(((2R,4S)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic acid |
| LCZ696 impurity 18 |
| (alphaS,gammaR)-gamma-[(3-Carboxy-1-oxopropyl)amino]-alpha-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester |
| 2R,4S-Sacubitril |
