CAS 27964-99-4|Poly-D-lysine hydrobromide (MW 30000-70000)
| Common Name | Poly-D-lysine hydrobromide (MW 30000-70000) | ||
|---|---|---|---|
| CAS Number | 27964-99-4 | Molecular Weight | 30000-70000 |
| Density | / | Boiling Point | 343.7±0.0 °C at 760 mmHg |
| Molecular Formula | (C6H14N2O2)x.xBrH | Melting Point | / |
| MSDS | USA | Flash Point | 161.7±0.0 °C |
Names
| Name | Lysine hydrobromide (1:1) |
|---|---|
| Synonym | More Synonyms |
BiologicalActivity
| Description | Poly-D-lysine hydrobromide (MW 30000-70000) is a synthetic polymeric substrate and is one of the most widely used substrate in neural cell culture. Poly-D-lysine hydrobromide (MW 30000-70000) removes proteinase K-resistant PrP from prion-infected SN56 neuroblastoma cells without affecting PrPC[1][2]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>Others |
| In Vitro | Poly-D-lysine is immunogenic in rabbits only when injected at low doses[1]. The approximate concentration of Poly-D-lysine (PDL) needed to lower the amount of PrPres by 50% corresponds to ~0.8 μg/mL or 50 nM[2]. |
| References | [1]. HansVermeersch, et al. Immunogenicity of poly-D-lysine, a potential polymeric drug carrier. Journal of Controlled Release. Volume 32, Issue 3, 1 December 1994, Pages 225-229. [2]. Zhou Xu, et al. Mechanistic insights into cellular alteration of prion by poly-D-lysine: the role of H2H3 domain. FASEB J. 2011 Oct;25(10):3426-35. |
Chemical & Physical Properties
| Boiling Point | 343.7±0.0 °C at 760 mmHg |
|---|---|
| Molecular Formula | (C6H14N2O2)x.xBrH |
| Molecular Weight | 30000-70000 |
| Flash Point | 161.7±0.0 °C |
| Exact Mass | 226.031677 |
| Appearance of Characters | lyophilized powder |
| Vapour Pressure | 0.0±0.0 mmHg at 25°C |
| Storage condition | −20°C |
| Water Solubility | Soluble in water. |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
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Synonyms
| MFCD00131934 |
| Lysine hydrobromide (1:1) |
| Lysine, hydrobromide (1:1) |
