Introduction：Basic information about CAS 1040085-99-1|Budesonide impurity C, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Budesonide impurity C |
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| CAS Number | 1040085-99-1 | Molecular Weight | 430.534 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 607.0±55.0 °C at 760 mmHg |
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| Molecular Formula | C25H34O6 | Melting Point | / |
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| MSDS | / | Flash Point | 204.6±25.0 °C |
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Names
| Name | (4aR,4bS,5S,6aS,7aR,10aR,11aS,11bS)-5-Hydroxy-7a-(hydroxymethyl)-4a,6a-dimethyl-9-propyl-4b,6,6a,7a,10a,11,11a,11b,12,13-decahydrochryseno[2,3-d][1,3]dioxole-2,7(4aH,5H)-dione |
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| Synonym | More Synonyms |
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Budesonide impurity C BiologicalActivity
| Description | Budesonide impurity C is an impurity of Budesonide. Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist[1][2]. |
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| Related Catalog | Research Areas >>CancerResearch Areas >>Inflammation/ImmunologySignaling Pathways >>GPCR/G Protein >>Glucocorticoid Receptor |
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| In Vitro | Budesonide is selective for human glucocorticoid receptor (hGR; EC50=45.7 pM) over mineralocorticoid receptors (EC50=7,620 pM) in CV-1 cells[1]. Budesonide (30 min prior to LPS) suppresses the activation of the NLRP3 inflammasome by LPS (100 ng/mL) plus ATP (5 mM) in macrophages (RAW 264.7 cells)[2]. |
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| References | [1]. Patrizia Ferraboschi, et al. Estimation and Characterisation of Budesonide Tablets Impurities. J Pharm Biomed Anal. 2008 Jul 15;47(3):636-40. [2]. Claudia Grossmann, et al. Transactivation via the Human Glucocorticoid and Mineralocorticoid Receptor by Therapeutically Used Steroids in CV-1 Cells: A Comparison of Their Glucocorticoid and Mineralocorticoid Properties. Eur J Endocrinol. 2004 Sep;151(3):397-406. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 607.0±55.0 °C at 760 mmHg |
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| Molecular Formula | C25H34O6 |
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| Molecular Weight | 430.534 |
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| Flash Point | 204.6±25.0 °C |
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| Exact Mass | 430.235535 |
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| LogP | 2.56 |
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| Vapour Pressure | 0.0±3.9 mmHg at 25°C |
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| Index of Refraction | 1.592 |
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| InChIKey | DRLZLIQUOCVRLM-PINIVEOHSA-N |
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| SMILES | CCCC1OC2CC3C4CCC5=CC(=O)C=CC5(C)C4C(O)CC3(C)C(=O)C2(CO)O1 |
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Synonyms
| (4aR,4bS,5S,6aS,7aR,10aR,11aS,11bS)-5-Hydroxy-7a-(hydroxymethyl)-4a,6a-dimethyl-9-propyl-4b,6,6a,7a,10a,11,11a,11b,12,13-decahydrochryseno[2,3-d][1,3]dioxole-2,7(4aH,5H)-dione |
| Chryseno[2,3-d][1,3]dioxole-2,7(4aH,5H)-dione, 4b,6,6a,7a,10a,11,11a,11b,12,13-decahydro-5-hydroxy-7a-(hydroxymethyl)-4a,6a-dimethyl-9-propyl-, (4aR,4bS,5S,6aS,7aR,10aR,11aS,11bS)- |
| Budesonide Impurity 3 |
