CAS 106758-54-7|Otophylloside B

Introduction：Basic information about CAS 106758-54-7|Otophylloside B, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Otophylloside B BiologicalActivity
3. Chemical & Physical Properties

Common Name	Otophylloside B
CAS Number	106758-54-7	Molecular Weight	923.134
Density	1.3±0.1 g/cm3	Boiling Point	898.5±65.0 °C at 760 mmHg
Molecular Formula	C₄₉H₇₈O₁₆	Melting Point	/
MSDS	/	Flash Point	249.0±27.8 °C

Names

Name	[(3S,8S,9R,10R,12R,13S,14R,17S)-17-acetyl-8,14,17-trihydroxy-3-[(2R,4S,5R,6R)-5-[(2S,4S,5R,6R)-5-[(2S,4R,5R,6R)-5-hydroxy-4-methoxy-6-methyl-tetrahydropyran-2-yl]oxy-4-methoxy-6-methyl-tetrahydropyran-2-yl]oxy-4-methoxy-6-methyl-tetrahydropyran-2-yl]oxy-10,13-dimethyl-1,2,3,4,7,9,11,12,15,16-decahydrocyclopenta[a]phenanthren-12-yl] (E)-3,4-dimethylpent-2-enoate

Otophylloside B BiologicalActivity

Description	Qingyangshengenin B, a C-21 steroidal glycoside isolated from Qingyangshen. Qingyangshengenin B protects against Aβ toxicity, which decreases Aβ deposition by decreasing the expression of Aβ at the mRNA level. Qingyangshengenin B has antiepileptic activity[1][2][3].
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease
References	[1]. Li JL, et al. Bioactive C21 Steroidal Glycosides from the Roots of Cynanchum otophyllum That Suppress the Seizure-like Locomotor Activity of Zebrafish Caused by Pentylenetetrazole. J Nat Prod. 2015 Jul 24;78(7):1548-55. [2]. Yang J, et al. Otophylloside B Protects Against Aβ Toxicity in Caenorhabditis elegans Models of Alzheimer's Disease. Nat Prod Bioprospect. 2017 Apr;7(2):207-214. [3]. Li X, et al. Antiepileptic C21 steroids from the roots of Cynanchum otophyllum. J Asian Nat Prod Res. 2015;17(7):724-32.

Description

Qingyangshengenin B, a C-21 steroidal glycoside isolated from Qingyangshen. Qingyangshengenin B protects against Aβ toxicity, which decreases Aβ deposition by decreasing the expression of Aβ at the mRNA level. Qingyangshengenin B has antiepileptic activity[1][2][3].

Related Catalog

Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease

References

[1]. Li JL, et al. Bioactive C21 Steroidal Glycosides from the Roots of Cynanchum otophyllum That Suppress the Seizure-like Locomotor Activity of Zebrafish Caused by Pentylenetetrazole. J Nat Prod. 2015 Jul 24;78(7):1548-55.

[2]. Yang J, et al. Otophylloside B Protects Against Aβ Toxicity in Caenorhabditis elegans Models of Alzheimer's Disease. Nat Prod Bioprospect. 2017 Apr;7(2):207-214.

[3]. Li X, et al. Antiepileptic C21 steroids from the roots of Cynanchum otophyllum. J Asian Nat Prod Res. 2015;17(7):724-32.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	898.5±65.0 °C at 760 mmHg
Molecular Formula	C₄₉H₇₈O₁₆
Molecular Weight	923.134
Flash Point	249.0±27.8 °C
Exact Mass	922.528992
LogP	6.29
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.563
InChIKey	YLHXSKZGPASTOD-ZMZOTGGVSA-N
SMILES	COC1CC(OC2C(C)OC(OC3C(C)OC(OC4CCC5(C)C(=CCC6(O)C5CC(OC(=O)C=C(C)C(C)C)C5(C)C(O)(C(C)=O)CCC65O)C4)CC3OC)CC2OC)OC(C)C1O
Storage condition	2-8℃

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