CAS 125580-28-1|[Leu31,Pro34]-Neuropeptide Y (porcine)

Introduction:Basic information about CAS 125580-28-1|[Leu31,Pro34]-Neuropeptide Y (porcine), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common Name[Leu31,Pro34]-Neuropeptide Y (porcine)
CAS Number125580-28-1Molecular Weight4222.63
Density/Boiling Point/
Molecular FormulaC190H286N54O56Melting Point/
MSDS/Flash Point/

Names

Name[Leu31, Pro34]-Neuropeptide Y porcine

[Leu31,Pro34]-Neuropeptide Y (porcine) BiologicalActivity

Description[Leu31,Pro34]- Neuropeptide Y (porcine), a Neuropeptide Y (NPY) analog, is a selective NPY Y1 receptor agonist. [Leu31,Pro34]- Neuropeptide Y (porcine) exhibits anxiolytic effects[1][2].
Related CatalogResearch Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>Neuropeptide Y Receptor
Target

NPY Y1 receptor

In Vivo[Leu31,Pro34]-Neuropeptide Y (porcine) displaces radiolabeled NPY from cells that express Y1 receptors in a series of human neuroblastoma cell lines and on rat PC-12 cells[1].
References

[1]. Fuhlendorff J, et, al. [Leu31, Pro34]neuropeptide Y: a specific Y1 receptor agonist. Proc Natl Acad Sci U S A. 1990 Jan;87(1):182-6.

[2]. Kokare DM, et, al. Interaction between neuropeptide Y and alpha-melanocyte stimulating hormone in amygdala regulates anxiety in rats. Brain Res. 2005 May 10;1043(1-2):107-14.

Chemical & Physical Properties

Molecular FormulaC190H286N54O56
Molecular Weight4222.63
InChIKeyZNBZLZXDILRJJT-CCPZSHQESA-N
SMILESCCC(C)C(NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(Cc1c[nH]cn1)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CO)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CCCNC(=N)N)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C1CCCN1C(=O)C(C)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)CNC(=O)C1CCCN1C(=O)C(CC(N)=O)NC(=O)C(CC(=O)O)NC(=O)C1CCCN1C(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C1CCCN1C(=O)C(N)Cc1ccc(O)cc1)C(=O)NC(CC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(C(=O)NC(CCCNC(=N)N)C(=O)N1CCCC1C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc1ccc(O)cc1)C(N)=O)C(C)O
Storage condition−20°C

Safety Information

WGK Germany3
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