CAS 12583-68-5|pTH (1-34) (bovine)
| Common Name | pTH (1-34) (bovine) | ||
|---|---|---|---|
| CAS Number | 12583-68-5 | Molecular Weight | 4108.71 |
| Density | / | Boiling Point | / |
| Molecular Formula | C183H288N54O50S2 | Melting Point | / |
| MSDS | USA | Flash Point | / |
Names
| Name | Parathyroid Hormone(1-34) Bovine |
|---|---|
| Synonym | More Synonyms |
pTH (1-34) (bovine) BiologicalActivity
| Description | Parathyroid Hormone (1-34), bovine is a potent parathyroid hormone (PTH) receptor agonist. Parathyroid Hormone (1-34), bovine increases calcium and inorganic phosphate levels in vivo. Parathyroid Hormone (1-34), bovine can be used for th reseach of osteoporosis[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>Thyroid Hormone ReceptorResearch Areas >>Metabolic Disease |
| In Vitro | Parathyroid Hormone (1-34), bovine (0.1-100 ng/mL; 2-20 days) are added to the medium, it inhibits osteoblast proliferation in a dose-dependent manner. In another group, bPTH are added to the culture medium from day 1 to day 10, but not from days 11 to 20, a rebound of proliferation is observed in the PTH Day 1–10 group after bPTH withdrawal[1]. Parathyroid Hormone (1-34), bovine (0.1-100 ng/mL; 2-20 days) induces diverse effects on the calcium and phosphorus content of culture medium. The calcium and phosphorus content of culture medium in the PTH-C 100 ng/mL group are higher than in teh control group[1]. Cell Proliferation Assay[1] Cell Line: MC3T3-E1 cells Concentration: 0.1-100 ng/mL Incubation Time: 2-20 days Result: Resulted a decrease of osteoblast proliferationin concentration-dependent manner. Resulted in a rebound of proliferation when PTH withdrawal. |
| In Vivo | Parathyroid Hormone (1-34)(subcutaneous injection; 80 μg/kg; 5 days) increases serum osteocalcin concentrations without changing serum inorganic phosphate or calcium concentrations in either group of old animals. Serum 1,25-dihydroxyvitamin D concentrations are significantly higher in the PTH-treated senile female rats than the sex-matchedvehicle-treated controls[1]. |
| References | [1]. B H Mitlak, et al. Intermittent administration of bovine PTH-(1-34) increases serum 1,25-dihydroxyvitamin D concentrations and spinal bone density in senile (23 month) rats. J Bone Miner Res. 1992 May;7(5):479-84. [2]. M Takigawa, et al. Studies on chondrocytes from mandibular condylar cartilage, nasal septal cartilage, and spheno-occipital synchondrosis in culture. I. Morphology, growth, glycosaminoglycan synthesis, and responsiveness to bovine parathyroid hormone (1-34). J Dent Res. 1984 Jan;63(1):19-22. |
Chemical & Physical Properties
| Molecular Formula | C183H288N54O50S2 |
|---|---|
| Molecular Weight | 4108.71 |
| InChIKey | BHCZZGBILISWFT-KANWXXSKSA-N |
| SMILES | CCC(C)C(NC(=O)C(CCC(=O)O)NC(=O)C(CO)NC(=O)C(NC(=O)CN)C(C)C)C(=O)NC(CCC(N)=O)C(=O)NCC(=O)NC(CCSC)C(=O)NC(Cc1cnc[nH]1)C(=O)NC(CC(N)=O)C(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(Cc1cnc[nH]1)C(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CO)C(=O)NC(CCSC)C(=O)NC(CCC(=O)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(C(=O)NC(CCC(=O)O)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCC(N)=O)C(=O)NC(CC(=O)O)C(=O)NC(C(=O)NC(Cc1cnc[nH]1)C(=O)NC(CC(N)=O)C(=O)NC(Cc1ccccc1)C(=O)O)C(C)C)C(C)C |
| Storage condition | -20°C |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
Articles27
More Articles| Thyroid hormones enhance the biomechanical functionality of scaffold-free neocartilage. Arthritis. Res. Ther. 17 , 28, (2015) The aim of this study was to investigate the effects of thyroid hormones tri-iodothyronine (T3), thyroxine (T4), and parathyroid hormone (PTH) from the parathyroid glands, known to regulate the develo... | |
| Identification of a novel parathyroid hormone-responsive gene in human osteoblastic cells. Bone 24(4) , 305-13, (1999) Parathyroid hormone (PTH) is a potent stimulator of osteoblastic cell function in vitro and bone resorption and formation in vivo; however, the details of the molecular mechanism(s) responsible for PT... | |
| Functional properties of a synthetic chicken parathyroid hormone-related protein 1-36 fragment. J. Bone Miner Res. 9(7) , 1041-6, (1994) The biologic activities of human parathyroid hormone-related protein [hPTHrP(1-34] and bovine PTH [bPTH(1-34)] are remarkably similar despite marked sequence divergence in their primary binding domain... |
Synonyms
| MFCD00147847 |
