CAS 11032-79-4|α-bungarotoxin
Introduction：Basic information about CAS 11032-79-4|α-bungarotoxin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | α-bungarotoxin | ||
|---|---|---|---|
| CAS Number | 11032-79-4 | Molecular Weight | / |
| Density | / | Boiling Point | / |
| Molecular Formula | C338H528N97O105S11 | Melting Point | / |
| MSDS | / | Flash Point | / |
Names
| Name | α-Bungarotoxin |
|---|
α-bungarotoxin BiologicalActivity
| Description | α-Bungarotoxin is a competitive antagonist at nicotinic acetylcholine receptors (nAChRs). α-Bungarotoxin, a selective α7 receptor blocker, blocks α7 currents with an IC50 of 1.6 nM and has no effects on α3β4 currents at concentrations up to 3 μM[1][2]. |
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| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>nAChRSignaling Pathways >>Neuronal Signaling >>nAChRResearch Areas >>Neurological Disease |
| In Vitro | α-Bungarotoxin binds specifically and with high affinity to the nicotinic acetylcholine receptor and competes with binding of the natural ligand. α-Bungarotoxin (α-BTX), is a potent competitive inhibitors of nicotinic acetylcholine receptor function and is highly toxic due to functional blockade of AcChoRs at the neuromuscular junction[3]. |
| References | [1]. Hannan S, et al. Snake neurotoxin α-bungarotoxin is an antagonist at native GABA(A) receptors. Neuropharmacology. 2015;93:28-40. [2]. López MG, et al. Unmasking the functions of the chromaffin cell alpha7 nicotinic receptor by using short pulses of acetylcholine and selective blockers. Proc Natl Acad Sci U S A. 1998;95(24):14184-14189. [3]. Balass M, et al. The alpha-bungarotoxin binding site on the nicotinic acetylcholine receptor: analysis using a phage-epitope library. Proc Natl Acad Sci U S A. 1997;94(12):6054-6058. |
Chemical & Physical Properties
| Molecular Formula | C338H528N97O105S11 |
|---|---|
| InChIKey | LYTCVQQGCSNFJU-UHFFFAOYSA-N |
| SMILES | C=C(C=O)CC1CC(O)C2(C)OC3CC4OC5CC6(C)OC7(C)CCC8OC9CC%10(C)OC%11C(C)=CC(=O)OC%11CC%10OC9CC(C)C8OC7CC6OC5(C)CC=CC4OC3CC2O1 |
