Introduction：Basic information about CAS 462605-73-8|Adhesamine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Adhesamine |
|---|
| CAS Number | 462605-73-8 | Molecular Weight | 670.505 |
|---|
| Density | / | Boiling Point | / |
|---|
| Molecular Formula | C24H32Cl4N8O2S2 | Melting Point | / |
|---|
| MSDS | / | Flash Point | / |
|---|
Names
| Name | Adhesamine |
|---|
| Synonym | More Synonyms |
|---|
Adhesamine BiologicalActivity
| Description | Adhesamine, dumbbell-shaped molecule, activates MAPK/FAK pathway. Adhesamine promotes adhesion and growth of mammalian cells. Adhesamine accelerates the differentiation and improves the survival of mice hippocampal neurons in primary culture[1]. |
|---|
| Related Catalog | Signaling Pathways >>Protein Tyrosine Kinase/RTK >>FAKResearch Areas >>Neurological Disease |
|---|
| Target | MAPK/FAK[1] |
|---|
| In Vitro | Adhesamine (20 μg/mL; 0-30 d) 促进小鼠原代培养海马神经元的附着并提高其存活率。Adhesamine 还诱导小鼠原代培养海马神经元神经突分支和快速分化[1]。 Adhesamine (20 μg/mL; 1 d, 3 d, 4 d) 细胞表面硫酸肝素诱导细胞粘附并激活 FAK 磷酸化。Adhesamine 还通过 MAPK 激活刺激神经突分化[1]。 |
|---|
| References | [1]. Hoshino M, et al. Adhesamine, a new synthetic molecule, accelerates differentiation and prolongs survival of primary cultured mouse hippocampal neurons. Biochem J. 2010 Mar 29;427(2):297-304. |
|---|
Chemical & Physical Properties
| Molecular Formula | C24H32Cl4N8O2S2 |
|---|
| Molecular Weight | 670.505 |
|---|
| Exact Mass | 668.084351 |
|---|
| InChIKey | WBOWBXMVVADADA-UHFFFAOYSA-L |
|---|
| SMILES | CSc1nc(Cl)c(C=O)c(N2CC[N+]3(CC2)CC[N+]2(CCN(c4nc(SC)nc(Cl)c4C=O)CC2)CC3)n1.[Cl-].[Cl-] |
|---|
Synonyms
| 3,12-Bis[6-chloro-5-formyl-2-(methylsulfanyl)-4-pyrimidinyl]-3,12-diaza-6,9-diazoniadispiro[5.2.5.2]hexadecane dichloride |
| 3,12-Diaza-6,9-diazoniadispiro[5.2.5.2]hexadecane, 3,12-bis[6-chloro-5-formyl-2-(methylthio)-4-pyrimidinyl]-, chloride (1:2) |
