CAS 9027-60-5|ec 4.1.3.3
Introduction：Basic information about CAS 9027-60-5|ec 4.1.3.3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | ec 4.1.3.3 | ||
|---|---|---|---|
| CAS Number | 9027-60-5 | Molecular Weight | 398.583 |
| Density | 1.000 g/cm3 | Boiling Point | / |
| Molecular Formula | C23H42O5 | Melting Point | / |
| MSDS | USA | Flash Point | / |
Names
| Name | N-Acetylneuraminic Acid Aldolase,from Microorganism |
|---|---|
| Synonym | More Synonyms |
ec 4.1.3.3 BiologicalActivity
| Description | N-Acetylneuraminic acid lyase (NAL) is a class I aldolase, is often used in biochemical studies. N-Acetylneuraminic acid lyase catalyzes the reversible condensation of pyruvate with N-acetyl-d-mannosamine (ManNAc) to yield the sialic acid N-acetylneuraminic acid (Neu5Ac)[1]. |
|---|---|
| Related Catalog | Research Areas >>Others |
| References | [1]. Daniels AD, et al. Reaction mechanism of N-acetylneuraminic acid lyase revealed by a combination of crystallography, QM/MM simulation, and mutagenesis. ACS Chem Biol. 2014 Apr 18;9(4):1025-32. |
Chemical & Physical Properties
| Density | 1.000 g/cm3 |
|---|---|
| Molecular Formula | C23H42O5 |
| Molecular Weight | 398.583 |
| Appearance of Characters | powder | slightly yellow |
| Storage condition | −20°C |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US) |
|---|---|
| Hazard Codes | Xi |
| Risk Phrases | 36/37/38 |
| Safety Phrases | 23-24/25-60-37-26-22 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles31
More Articles| Chemistry, metabolism, and biological functions of sialic acids. Adv. Carbohydr. Chem. Biochem. 40 , 131, (1982) | |
| Structural basis for substrate specificity and mechanism of N-acetyl-D-neuraminic acid lyase from Pasteurella multocida. Biochemistry 52(47) , 8570-9, (2013) N-Acetylneuraminate lyases (NALs) or sialic acid aldolases catalyze the reversible aldol cleavage of N-acetylneuraminic acid (Neu5Ac, the most common form of sialic acid) to form pyruvate and N-acetyl... | |
| Structural insights into the recovery of aldolase activity in N-acetylneuraminic acid lyase by replacement of the catalytically active lysine with γ-thialysine by using a chemical mutagenesis strategy. ChemBioChem. 14(4) , 474-81, (2013) Chemical modification has been used to introduce the unnatural amino acid γ-thialysine in place of the catalytically important Lys165 in the enzyme N-acetylneuraminic acid lyase (NAL). The Staphylococ... |
Synonyms
| MFCD00131656 |
