Introduction：Basic information about CAS 270076-60-3|Pristinamycin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Pristinamycin |
|---|
| CAS Number | 270076-60-3 | Molecular Weight | 866.958 |
|---|
| Density | 1.4±0.1 g/cm3 | Boiling Point | 1202.1±65.0 °C at 760 mmHg |
|---|
| Molecular Formula | C73H89N11O17 | Melting Point | / |
|---|
| MSDS | / | Flash Point | 680.8±34.3 °C |
|---|
Names
| Name | Pristinamycin |
|---|
| Synonym | More Synonyms |
|---|
Pristinamycin BiologicalActivity
| Description | Pristinamycin, produced by Streptomyces pristinaespiralis, is an orally active streptogramin-like antibiotic consisting of two chemically unrelated components: Pristinamycin I (PI) and Pristinamycin II (PII). Pristinamycin is highly active against many antibiotic-resistant pathogens, particularly Gram-positive bacteria, including Methicillin-resistant Staphylococcus aureus (MRSA), Vancomycin-resistant S. aureus (VRSA) and Enterococcus faecium (VREF)[1]. |
|---|
| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial |
|---|
| In Vitro | In-vitro studies show pristinamycin to inhibit Staphylococci and Streptococci, including Erythromycin highly-resistant organisms, at a concentration of less than or equal to 0.78 mg/l[2]. |
|---|
| In Vivo | To study Pristinamycin activity in vivo, mice infected IP with C. psittaci. Mortality in the control group was 70%. Three groups of mice received 25 mg/kg, 50 mg/kg and 100 mg/kg Pristinamycin respectively. The antibiotic was active in the 100 mg/kg dosage which is the therapeutic dosage[3]. |
|---|
| References | [1]. Meng J, et al. Improvement of pristinamycin I (PI) production in Streptomyces pristinaespiralis by metabolic engineering approaches. Synth Syst Biotechnol. 2017;2(2):130-136. Published 2017 Jun 8. [2]. Maskell JP, et al. Comparative in-vitro activity of erythromycin, vancomycin and pristinamycin. Infection. 1988;16(6):365-370. [3]. Orfila J, Haider F. Action de la pristinamycine sur les Chlamydia [Action of pristinamycin on Chlamydia]. Pathol Biol (Paris). 1984;32(5):443-445. |
|---|
Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
|---|
| Boiling Point | 1202.1±65.0 °C at 760 mmHg |
|---|
| Molecular Formula | C73H89N11O17 |
|---|
| Molecular Weight | 866.958 |
|---|
| Flash Point | 680.8±34.3 °C |
|---|
| Exact Mass | 866.396301 |
|---|
| LogP | -0.45 |
|---|
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
|---|
| Index of Refraction | 1.650 |
|---|
Synonyms
| Pristinamycin IA |
| Vernamycin B α |
| MFCD01778146 |
| 2-Pyridinecarboxamide, N-[(6R,9S,10R,13S,15aS,22S,24aS)-22-[[4-(dimethylamino)phenyl]methyl]-6-ethyldocosahydro-10,23-dimethyl-5,8,12,15,17,21,24-heptaoxo-13-phenyl-12H-pyrido[2,1-f]pyrrolo[2,1-l][1,4,7,10,13,16]oxapentaazacyclononadecin-9-yl]-3-hydroxy- |
| N-{(6R,9S,10R,13S,15aS,22S,24aS)-22-[4-(Dimethylamino)benzyl]-6-ethyl-10,23-dimethyl-5,8,12,15,17,21,24-heptaoxo-13-phenyldocosahydro-12H-pyrido[2,1-f]pyrrolo[2,1-l][1,4,7,10,13,16]oxapentaazacyclononadecin-9-yl}-3-hydroxy-2-pyridinecarboxamide |
| Ostreogrycin B |
| Streptogramin B |
